Results 51 to 60 of about 1,020,351 (295)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Evaluation of Neutron Capture Cross Sections and Covariances on 99Tc and 129I in the keV Energy Region

EPJ Web of Conferences, 2016
Neutron capture cross sections and covariances on radioactive 99Tc and 129I have been required for developing environmental load-reducing technology. Their evaluation was performed by using nuclear reaction calculation code CCONE and Baysian code KALMAN ...
Iwamoto Nobuyuki
doaj   +1 more source

Breakup of 8B+natZr at the sub-barrier energy of 26.5 MeV [PDF]

EPJ Web of Conferences
In our systematic research on reactions with weakly bound nuclei at suband nearbarrier energies, we have studied the system 8B+natZr at the sub-barrier energy of 26.5 MeV.
Palli K., Pakou A., Moro A. M., O’ Malley P. D., Acosta L., Sántzez-Bénitez A., Souliotis G., Aguilera E. F., Andrade E., Godos D., Sgouros O., Soukeras V., Agodi C., Bailey T. L., Bardayan D. W., Boomershine C., Brodeur M., Cappuzzello F., Caramichael S., Cavallaro M., Dede S., Dueñas J.A., Henning J., Lee K., Porter W.S., Rivero F., von Seeger W.   +26 more
doaj   +1 more source

Coulomb and nuclear effects in breakup and reaction cross sections

, 2016
We use a three-body Continuum Discretized Coupled Channel (CDCC) model to investigate Coulomb and nuclear effects in breakup and reaction cross sections.
Canto, L. Felipe, Descouvemont, Pierre, Hussein, Mahir S.   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The reaction pi N to pi pi N in a meson-exchange approach [PDF]

, 2006
A resonance model for two-pion production in the pion-nucleon reaction is developed that includes information obtained in the analysis of pion-nucleon scattering in a meson-exchange model. The baryonic resonances Delta(1232), N*(1440), N*(1520), N*(1535),
Afnan, Anisovich, Arndt, Aznauryan, Bernard, Bernard, Bernard, Bernard, Bernard, Fatemi), Fettes, Feuster, Gasparyan, Haymaker, Jaekel, Jensen, Kammano, Kermani), Krehl, Langgartner, Mobed, Nacher, Oset, Prakhov), S. Krewald, S. Schneider, Sassen, Tejedor, Tiator, Ulf-G. Meißner, Vereshagin, Vrana, Wolf   +32 more
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Breakup, fusion, and elastic scattering analysis of the 8B + 58Ni system at low energies with the continuum-discretized coupled channels method

EPJ Web of Conferences, 2014
We have performed continuum-discretized coupled channels (CDCC) calculations of the breakup of 8B on 58Ni in the energy interval 10 – 26 MeV in the c.m. system.
Belyaeva T. L., Amador-Valenzuela P., Aguilera E. F., Martinez-Quiroz E., Kolata J. J.   +4 more
doaj   +1 more source

$K^-$-Nucleus Scattering at Low and Intermediate Energies [PDF]

, 2002
We calculate $K^-$-nucleus elastic differential, reaction and total cross sections for different nuclei ($^{12}$C,$^{40}$Ca and $^{208}$Pb) at several laboratory antikaon momenta, ranging from 127 MeV to 800 MeV. We use different antikaon-nucleus optical
A. Baca, A. J. Melgarejo, A. Ramos, A. Sibirtsev, A.D. Martin, C. García-Recio, C. García-Recio, C.J. Batty, D. Jido, D. Marlow, D.V. Bugg, E. Friedman, E. Friedman, E. Friedman, E. Oset, E. Oset, G.P. Gopal, J. Nieves, J. Nieves, J. Nieves, J.A. Oller, N. Kaiser, N. Kaiser, S. Hirenzaki   +23 more
core   +3 more sources