Results 61 to 70 of about 8,388,417 (298)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Spatial and temporal variation of benthic fish assemblages during the extreme drought of 1997-98 (El Niño) in the middle rio Negro, Amazonia, Brazil

Neotropical Ichthyology
Spatial and temporal variation in the benthic fish composition, species richness, density and biomass were studied in the lower rio Branco and its confluence with the rio Negro during the 1997-98 dry season (September to February).
Mario J. F. Thomé-Souza, Ning Labbish Chao   +1 more
doaj   +1 more source

Exergy Analysis in Hydrogen-Air Detonation

Journal of Applied Mathematics, 2012
The main goal of this paper is to analyze the exergy losses during the shock and rarefaction wave of hydrogen-air mixture. First, detonation parameters (pressure, temperature, density, and species mass fraction) are calculated for three cases where the ...
Abel Rouboa, Valter Silva, Nuno Couto
doaj   +1 more source

Total Variation Diminishing Scheme for Adiabatic and Isothermal Magnetohydrodynamics

The Astrophysical Journal Supplement Series, 1998
In this paper a total variation diminishing (TVD) scheme is constructed for solving the equations of ideal adiabatic and isothermal MHD. It is based on an extremely efficient formulation of the MHD Riemann problems for either case. Piecewise linear interpolation is applied to the characteristic variables along with steepening of linearly degenerate ...
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Lattice Boltzmann simulation of multiphase fluid flows through the total variation diminishing with artificial compression scheme

, 2023
The total variation diminishing with artificial compression (TVD/AC) scheme is applied to the lattice Boltzmann multiphase model in order to introduce a new technique to solve the traditional lattice Boltzmann equation.
S Teng (13600789), H Ohashi (13598794), Y Chen (5099375)   +2 more
core  

Regional variation in the pronunciation of /s/ in the Dutch language area [PDF]

, 2019
This paper reports on an explorative sociophonetic study of the phoneme /s/ in the Dutch language area. Our aim is to investigate the regional variation in the realisation of this phoneme, and to test experimentally the observation of Collins & Mees ...
Heeren, W.F.L., Pinget, A.F., LS OZ Lexion en syntaxis, Ditewig, S., Pinget, A.C.H., ILS Variation, Ditewig, Sanne   +6 more
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Efficient three-dimensional high-resolution simulations of flow fields around cylinders

Journal of Ocean Engineering and Science, 2018
Few works use the fully three-dimensional computational fluid dynamic method to simulate the flow fields around the marine pipes with large aspect ratios due to the huge computation cost.
Hanxu Zheng, Jiasong Wang
doaj   +1 more source