Results 81 to 90 of about 8,388,417 (298)

On the curvature of the reporting function from objective reality to subjective feelings [PDF]

open access: yes, 2008
I suggest the idea of a reporting function, r(.), from reality to feelings. The ‘happiness’ literature claims we have demonstrated diminishing marginal utility of income. I show not, and that knowing r(.)’s curvature is crucial.
Oswald, Andrew J.
core   +1 more source

Regional variation of avoidable hospitalisations in a universal health care system: a register-based cohort study from Finland 1996−2013

open access: yesBMJ Open, 2019
Objectives A persistent finding in research concerning healthcare and hospital use in Western countries has been regional variation in the medical practices.
Kristiina Manderbacka   +3 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

open access: yesMolecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Aspects of Linguistic Variation [PDF]

open access: yes, 2018
This volume brings together papers on linguistic variation. It takes a broad perspective, covering not only crosslinguistic and diachronic but also intralinguistic and interspeaker variation, and examines phenomena ranging from negation and TAM over ...

core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Numerical modelling of flow pattern for high swirling flows

open access: yesEPJ Web of Conferences, 2015
This work focuses on the interaction of two coaxial swirling jets. High swirl burners are suitable for lean flames and produce low emissions. Computational Fluid Dynamics has been used to study the isothermal behaviour of two confined jets whose setup ...
Parra Teresa   +4 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Nonlinear Interpolation and Total Variation Diminishing Schemes

open access: yes, 1990
The Van Leer approach for the approximation of nonlinear scalar conservation laws is studied in one space dimension. The problem can be reduced to a nonlinear interpolation and we propose a convexity property for the interpolated values.
Dubois, François
core  

Influence of In-Cylinder Turbulence Kinetic Energy on the Mixing Uniformity within Gaseous-Fuel Engines under Various Intake Pressure Conditions

open access: yesEnergies
To explore the potential for further enhancing the gas mixing uniformity of natural gas (NG) engines, this paper identifies turbulent kinetic energy (TKE), which has an essential impact on gas mixing, as the entry point of the research.
Tianbo Wang   +6 more
doaj   +1 more source

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