Results 111 to 120 of about 45,782 (275)

Totally expanding multiplicative systems [PDF]

open access: yes, 2005
A single-matrix multiplicative system consists of an N×N nonnegative matrix Q and an N×1 semi-positive vector x(0). This system is said to be totally expanding if each entry of the sequence {Qnx(0)}n=0,1,… is unbounded.
Rothblum, Uriel G., Denardo, Eric V.
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Accurate computation of the Moore-Penrose inverse of strictly totally positive matrices [PDF]

open access: yes, 2019
The computation of the Moore-Penrose inverse of structured strictly totally positive matrices is addressed. Since these matrices are usually very ill-conditioned, standard algorithms fail to provide accurate results.
Marco García, Ana   +1 more
core   +1 more source

Intraventricular solitary fibrous tumor

open access: yesChinese Journal of Contemporary Neurology and Neurosurgery, 2015
Background Solitary fibrous tumor (SFT) is a mesenchymal neoplasm of specialized fibroblastic lineage, which frequently occurs in the subcutaneous and deep soft tissue of pleura,mediastinum, head and neck, extremities and trunk.
Yan-yang CHEN   +3 more
doaj  

Clonal and horizontal transmission of carbapenem-resistant Enterobacterales strains and genes via flies

open access: yesGut Pathogens
Background Antimicrobial resistance (AMR) is one of the most pressing global public health challenges; in particular, the rapid dissemination of carbapenem-resistant Enterobacterales (CRE) is emerging as a significant concern worldwide. Flies, serving as
Jialiang Xu   +11 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Generalized totally nonnegative matrices [PDF]

open access: yes, 2002
We define a new class of generalized totally nonnegative matrices, shortly GTN-matrices, over a noncommutative ring with identity and a positive part.
Miroslav Fiedler   +3 more
core   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Some extremal problems for strictly totally positive matrices [PDF]

open access: yes, 1985
For a strictly totally positive M × N matrix A we show that the ratio ∥Ax∥p∥x∥p has exactly R = min{ M, N} nonzero critical values for each fixed p ϵ (1, ∞). Letting λi denote the ith critical value, and xi an associated critical vector, we show that λ1 >
Pinkus, A.
core   +1 more source

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