Results 101 to 110 of about 45,774 (276)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
, 2018 We study the combinatorial description of the LDU-decomposition of totally positive matrices. We give a description of the lower triangular L, the diagonal D, and the upper triangular U matrices of the LDU-decomposition of totally positive matrices in ...
Muhammad ElGebali +3 more
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Some properties of totally positive matrices
, 1976 Let A be a real n × n matrix. A is TP (totally positive) if all the minors of A are nonnegative. A has an LU-factorization if A = LU, where L is a lower triangular matrix and U is an upper triangular matrix. The following results are proved: Theorem 1: A
Cryer, Colin W.
core +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
An Interlacing Property of Eigenvalues of Strictly Totally Positive Matrices
, 1998 . We prove results concerning the interlacing of eigenvalues of principal submatrices of strictly totally positive matrices. x1. Introduction The central results concerning eigenvalues and eigenvectors of strictly totally positive (STP) matrices were ...
Allan Pinkus, Pinkus, Allan
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
On the characterization of totally nonpositive matrices [PDF]
, 2016 The final publication is available at Springer via http://dx.doi.org/10.1007/s40324-016-0073-1[EN] A nonpositive real matrix $A= (a_{ij})_{1 \leq i, j \leq n}$ is said to be totally nonpositive (negative) if all its minors are nonpositive (negative) and ...
Pelaez, María J. +2 more
core +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source