Results 61 to 70 of about 78,317 (265)
The cellular and synaptic architecture of the mechanosensory dorsal horn [PDF]
, 2017 The deep dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic tools for defining neuronal components and functions of the dorsal horn LTMR ...
Abraira +80 more
core +1 more source
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source
Electric Power Systems Research, 2023 An extensive field experiment was conducted to investigate the effects of earth -enhancing compounds on earthing systems. Four identical vertical earth rods were installed, each encased in concrete, Bentonite, and two commercial enhancing materials. Lightning impulse signals were injected into all electrode arrangements, and the measured responses were
Chandimal, Lasantha +5 more
openaire +2 more sources
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source
The Effect of Soil Type on Touch Voltage and Step Voltage in the Grid Grounding System
ELKHAThe grounding system is one of the security systems in substations to channel excess voltage caused by lightning strikes that occur at substations, as well as electrical equipment. To design a grounding system, there are several factors that must be considered, including the type of soil, the configuration of the grounding system, the resistivity of ...
Ayu Fitriani +2 more
openaire +2 more sources
Advanced Engineering Materials, EarlyView.This article presents the NFDI‐MatWerk Ontology (MWO), a Basic Formal Ontology‐based framework for interoperable research data management in materials science and engineering (MSE). Covering consortium structures, research data management resources, services, and instruments, MWO enables semantic integration, Findable, Accessible, Interoperable, and ...
Hossein Beygi Nasrabadi +4 more
wiley +1 more source
MicroSQUID Force microscopy in a dilution refrigerator [PDF]
, 2014 We present a new generation of a scanning MicroSQUID microscope operating in an inverted dilution refrigerator. The MicroSQUIDs have a size of 1.21$ \ \mu$m\textsuperscript{2} and a magnetic flux sensitivity of 120 $\mu\Phi_{0} / \sqrt{\textrm{Hz}}$ and ...
Castellazzi, Pauline +6 more
core +3 more sources
Advanced Engineering Materials, EarlyView.This study investigates laser‐based oxide removal of Cu inserts in oxygen‐free conditions and examines long‐term oxidation kinetics and surface chemistry under different atmospheres via X‐ray photoelectron spectroscopy. Al–Cu compound casting with differently oxidized surfaces is performed, and intermetallic phase formation, morphology, and thermal ...
Timon Steinhoff +9 more
wiley +1 more source