Results 71 to 80 of about 191,063 (302)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Guided Poster Tour [PDF]

open access: yesMovement Disorders, 2016
Objective\ud 1) To identify patient barriers to help-seeking for non-motor symptoms (NMS) from their Parkinson’s healthcare provider,\ud 2) To determine whether barriers are symptom specific (e.g. embarrassment disclosing sexual problems) or patient specific (e.g.
Hurt, C. S.   +4 more
openaire   +2 more sources

Using ICT to support public and private community memories: case studies and lessons learned [PDF]

open access: yes, 2006
Information communication technologies (ICTs) enable the development of memories across a variety of communities. We identify a spectrum of deployment from private through to open public spaces.
Collins, T.   +4 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Guiding the Dark and Secondary Trauma Syndrome: Tour Guides’ Coping Mechanisms for Guiding in Dark Tourism Sites

open access: yesJournal of Tourismology, 2018
This research is a part of PhD research exploring how tour guides interpret the dark chapters of Berlin’s history. The theoretical framework brings together the strands of dark tourism, tour guide, and interpretation literature.
Asaf Leshem
doaj   +3 more sources

THE IMPORTANCE OF TOUR GUIDES TRAINING IN ADJARA REGION, GEORGIA

open access: yesAgora International Journal of Economical Sciences
The aim of the study was to analyze the influence of training on guides’ job satisfaction, as well as the relationship between service satisfaction and demographic variables.
Tamari Karbaia
doaj   +1 more source

A guided tour of tour guiding

open access: yes, 2004
This has been my second summer as the IOT Tour Coordinator, last time it was in 2002. I took a summer off from this, and there were lots of changes. The building is bigger, the staff has changed a little bit, there is even a new DG. Some things are the same. People here are easy to get along with, there is a new batch of work term students that are fun
openaire   +1 more source

Tourism-themed internet portals – are new media creating a new tourist? A case study of Polish students [PDF]

open access: yes, 2017
Internet media have an influence on many tourism-related issues. This article presents the results of research into the role of tourism-themed portals in the trips taken by Polish university students between 2010 and 2012.
Jagnuszewska, Anna, Jażdżewska, Iwona
core   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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