Results 41 to 50 of about 481,513 (273)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Energies, 2022 Transmission towers are prone to collapse under strong wind load, resulting in significant economic losses. In order to investigate the collapse mechanism and failure modes of the transmission tower under strong wind load and whether the wind vibration ...
Junkuo Li +8 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Applied SciencesTransmission lines are usually located outdoors and are subjected to wind loads year-round. When a fire occurs, transmission towers are exposed to the combined effects of fire and wind loads. This paper investigates the impact of high temperatures on the
Xiwei He +4 more
doaj +1 more source
Sensors, 2023 Lightning strikes are the main cause of transmission line faults, and the accurate lightning current number is an important basis to guide scientific lightning protection.
Jinming Ge, Yibo Yin, Wei Wang
doaj +1 more source
Effects of bolt slippage on the wind induced responses of transmission tower line system [PDF]
, 2017 The wind induced responses of transmission tower line system are studied by finite element method. Firstly, a slip model considering eccentricity and bolt joint slippage in diagonal bracings, tower legs and tower head is built by ANSYS.
Haibo Chen +3 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
High-voltage transmission tower-line system subjected to disaster loads
Progress in Natural Science, 2006 The high-voltage power transmission system is an important lifeline structure. It is significant for wide researches on the features and ability of the system subjected to earthquake and environmen...
Li Hongnan, Bai Haifeng
openaire +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source