Results 91 to 100 of about 236,959 (307)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Human health risk assessment of potentially toxic elements (PTEs) from environmental matrices [PDF]
In assessing human health risk of potentially toxic elements (PTEs), it is not the concentration of PTEs in the environmental matrices that is of greatest concern but the fraction that is absorbed into the body via the exposure pathways.
Elom, Nwabueze
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, 2009 Cílem této bakalářské práce bylo zabývat se výskytem vybraných toxických prvků v životním prostředí. Konkrétně jsou zde uvedeny olovo, arzen, rtuť a kadmium.
Sobková, Veronika
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Distributions of dissolved toxic elements during seasonal variation in Kuantan river, Pahang, Malaysia [PDF]
, 2014 The concentrations of toxic metals were determined in estuary and freshwater zones from Kuantan River basin. Water samples were collected from the surface and bottom layers of nine sampling stations, from the downstream of the estuary towards the ...
Yunus, Kamaruzzaman +4 more
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Toxic Effects of Trace Element Excess
Veterinary Clinics of North America: Food Animal Practice, 1991 Excesses of many trace elements can cause direct toxic effects to cattle as well as indirect effects that can cause a secondary deficiency of other trace elements. Clinical signs may vary from poor growth and feed utilization to neurologic disorders. Toxic effects vary with the specific trace element in question, the total amount of that element in the
Thompson, L. J. +2 more
openaire +3 more sources
Toxic elements as biomarkers for breast cancer: a meta-analysis study [PDF]
, 2018 Leila Jouybari,1 Marzieh Saei Ghare Naz,2 Akram Sanagoo,1 Faezeh Kiani,3 Fatemeh Sayehmiri,4 Kourosh Sayehmiri,5 Ali Hasanpour Dehkordi6 1Nursing Research Center, Goletsan University of Medical Sciences, Gorgan, Iran; 2Student Research Committee, School ...
Jouybari L +6 more
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