Results 131 to 140 of about 236,959 (307)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
CONCENTRATIONS OF ESSENTIAL AND TOXIC ELEMENTS IN HUMAN MILK AND INFANT FORMULAS [PDF]
, 2016 Human milk represents the most suitable pattern of nutrients to meet the physiological requirements of the young infant and exclusive breast feeding is recommended up to 6 months of age. When breast feeding is not possible, infant formulas are often used
Reghizzi, J +7 more
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Role of toxic and essential elements in sleep duration of patients with cardiovascular diseases
Scientific ReportsSleep disorders are a common aspect of cardiovascular diseases (CVDs) that can negatively impact a patient’s quality of life, trigger coronary events, accelerate disease progression, and influence patient survival.
Namam Ali Azadi +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Toxic Trace-Element Content of Coronary-Artery Plaques [PDF]
, 1994 WOS: A1994PN40300003In this study, toxic trace element content of 16 coronary artery plaques obtained from 16 patients with coronary artery disease was analyzed and possible correlations were investigated between toxic trace elements and major component ...
Akyol, O +6 more
core
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Evaluation of the Main Potentially Toxic Elements and Bioindicator Organisms [PDF]
Environmental quality is a recurring concern in the area of public health, as the presence of contaminants can cause changes in the environment and affect human life.
Mascarenhas, Maria do Socorro +2 more
core +2 more sources