Medical Marijuana-Induced Tacrolimus Toxicity. [PDF]
As both recreational and therapeutic marijuana use increases in the US, more attention is being paid to its direct medical and psychoactive effects. One crucial dimension is the potential for marijuana or marijuana-derived therapies to interact with ...
Chism, Keira, Moadel, Daniel
core +1 more source
Cardiovascular and hepatic toxicity of cocaine: potential beneficial effects of modulators of oxidative stress [PDF]
Oxidative stress (OS) is thought to play an important role in the pharmacological and toxic effects of various drugs of abuse. Herein we review the literature on the mechanisms responsible for the cardiovascular and hepatic toxicity of cocaine with ...
Antonilli, Letizia +5 more
core +4 more sources
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
In Vivo Renal Clearance, Biodistribution, Toxicity of Gold nanoclusters
Gold nanoparticles have shown great prospective in cancer diagnosis and therapy, but they can not be metabolized and prefer to accumulate in liver and spleen due to their large size.
Fan, Fei-Yue +5 more
core +1 more source
Phenylboronic acid-diol crosslinked 6-O-vinylazeloyl-d-galactose nanocarriers for insulin delivery [PDF]
A new block polymer named poly 3-acrylamidophenylboronic acid-b-6-O–vinylazeloyl-d-galactose (p(AAPBA-b-OVZG)) was prepared using 3-acrylamidophenylboronic acid (AAPBA) and 6-O-vinylazeloyl-D-galactose (OVZG) via a two-step procedure involving S-1 ...
Bremner, David H. +5 more
core +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
A brief introduction to the United States CDC Laboratory Response Network for Chemical Threats
The United States Centers for Disease Control and Prevention (CDC) Laboratory Response Network for Chemical Threats (LRN-C) is a network of more than 50 primarily local public health laboratories covering all states and regions of the United States.
Xuefei LENG, Yimin WEN
doaj +1 more source
Tissue distribution patterns of solubilized metals from internalized tungsten alloy in the F344 rat
Because of its unique physical and chemical properties, tungsten has been increasingly utilized in a variety of civilian and military applications. This expanded use also raises the risk of human exposure through internalization by various routes.
Vernieda B. Vergara +2 more
doaj +1 more source
Antioxidant,antimicrobial and toxicological properties of Schinus molle L. essential oils [PDF]
Ethnopharmacological relevance: Schinus molle L. has been used in folk medicine as antibacterial, antiviral, topical antiseptic, antifungal, antioxidant, anti-inflammatory, anti-tumoural as well as antispasmodic and analgesic; however, there are few ...
Arantes, S. +4 more
core +1 more source
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source

