Results 111 to 120 of about 2,730,331 (342)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Survey of sediment quality in Sabine Lake, Texas and vicinity [PDF]

, 1999
The toxicity of sediments in Sabine Lake, Texas, and adjoining Intracoastal Waterway canals was determined as part of bioeffects assessment studies managed by NOAA’s National Status and Trends Program.
Anderson, Jack W., Biedenbach, James, Carr, R. Scott, Hameedi, M. Jawed, Harmon, Michelle, Johnson, Tom, Long, Edward R., Mueller, Cornelia, Presley, Bobby J., Scott, K. John, Sloane, Gail M., Wade, Terry L.   +11 more
core  

Asymmetric triplex metallohelices with high and selective activity against cancer cells [PDF]

, 2014
Small cationic amphiphilic α-helical peptides are emerging as agents for the treatment of cancer and infection, but they are costly and display unfavourable pharmacokinetics.
A Krishan, ACG Hotze, Alan D. Faulkner, C Schulze Isfort, CA Hunter, CR Rice, D Fu, Daniel H. Simpson, David I. Roper, David J. Fox, DH Appella, DP Lane, E Gavathiotis, EC Constable, FE Hahn, Guy Clarkson, H Yu, I Nicoletti, JM Andrews, JM Davis, JM Lehn, L Cardo, LD Walensky, M Albrecht, M Kajstura, M Zanetti, MJ Hannon, MW Schmidt, Peter Scott, Pratik Gurnani, Qasem M. A. Abdallah, Rebecca A. Kaner, RJ Deeth, RJ Deeth, Roger M. Phillips, RP Cheng, S Grimme, S Grimme, S Torelli, SE Howson, SE Howson, SE Howson, SE Howson, SE Howson, SJ Baker, SJ Coles, Suzanne E. Howson, SX Ren, T Takahashi, UHN Dürr, V Azzarito, V Brabec, WKK Wu, WM Bonner, ZH Siddik   +54 more
core   +2 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

A brief introduction to the United States CDC Laboratory Response Network for Chemical Threats

Zhongguo gonggong weisheng
The United States Centers for Disease Control and Prevention (CDC) Laboratory Response Network for Chemical Threats (LRN-C) is a network of more than 50 primarily local public health laboratories covering all states and regions of the United States.
Xuefei LENG, Yimin WEN
doaj   +1 more source

Biomass structure of Pinus sylvestris and Betula pendula forest ecosystems in pollution gradient near copper plant on the Southern Ural [PDF]

, 2019
In the gradient of pollution from the Karabash copper smelter in the Southern Urals (55 degrees 29' N, 60 degrees 13' E) in predominantly pure Scots pine and white birch stands, 12 and 34 sample plots are established, respectively, on which 42 and 56 ...
Chasovskikh, V. P., Usoltsev, V. A., Zukow, W.   +2 more
core  

Mancozeb impairs the ultrastructure of mouse granulosa cells in a dose-dependent manner [PDF]

, 2018
Mancozeb, an ethylene bis-dithiocarbamate, is widely used as a fungicide and exerts reproductive toxicity in vivo and in vitro in mouse oocytes by altering spindle morphology and impairing the ability to fertilize.
Antonouli, S, Belli, M, Bernardi, S, Bianchi, S, Cecconi, S, Familiari, G, Macchiarelli, G, Miglietta, S, Nottola, Sa, Palmerini, Mg   +9 more
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Toxic Epidermal Necrolysis after Pemetrexed and Cisplatin for Non-Small Cell Lung Cancer in a Patient with Sharp Syndrome [PDF]

, 2012
Background: Pemetrexed is an antifolate drug approved for maintenance and second-line therapy, and, in combination with cisplatin, for first-line treatment of advanced nonsquamous non-small cell lung cancer.
Aguiar D, Azukizawa H, Barlési F, Bastuji-Garin S, Belani CP, Bosch-Barrera J, Bracke A, Cohen MH, Cornelia Then, Daniel Müller, Del Pozzo-Magana BR, Fuld AD, Grader-Beck T, Harr T, Iung, Jobst C. von Einem, Kardaun SH, Lopes G, Martin Reincke, Michael J. Flaig, Mockenhaupt M, Rudolf M. Huber, Schneck J, Seiwert TY, Shih C, Tan SK, Tummino C, Vitiello M, Yun SJ   +28 more
core   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source