Results 41 to 50 of about 2,541,601 (314)

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Horizontal Honey-Bee Larvae Rearing Plates Can Increase the Deformation Rate of Newly Emerged Adult Honey Bees

Insects, 2021
Rearing honey bee larvae in vitro is an ideal method to study honey bee larval diseases or the toxicity of pesticides on honey bee larvae under standardized conditions. However, recent studies reported that a horizontal position may cause the deformation
Juyeong Kim, Kyongmi Chon, Bo-Seon Kim, Jin-A Oh, Chang-Young Yoon, Hong-Hyun Park, Yong-Soo Choi   +6 more
doaj   +1 more source

Too toxic

Nursing Critical Care, 2007
Firm up on the facts and considerations associated with acetaminophen toxicity.
Scott, Saccomano, Deborah A, Deluca
openaire   +4 more sources

Scientific Opinion on the re-evaluation of Quinoline Yellow (E 104) as a food additive:Question No EFSA-Q-2008-223 [PDF]

, 2009
The Panel on Food Additives and Nutrient Sources added to Food provides a scientific opinion re-evaluating the safety of Quinoline Yellow (E 104). Quinoline Yellow has been previously evaluated by the Joint FAO/WHO Expert Committee on Food Additives ...
Bal-Price, Bateman, BIBRA (The British Industrial Biological Research Association), Blevins, EC (European Commission), EFSA (European Food Safety Authority), EFSA (European Food Safety Authority), Fuglsang, Fuglsang, Fujita, Hannuksela, Hansen, Hollstein, JECFA (Joint FAO/WHO Expert Committee on Food Additives), JECFA (Joint FAO/WHO Expert Committee on Food Additives), JECFA (Joint FAO/WHO Expert Committee on Food Additives), JECFA (Joint FAO/WHO Expert Committee on Food Additives), JECFA (Joint FAO/WHO Expert Committee on Food Additives), Juhlin, Larsen, Lau, LEMM, Lu, Lück, Macioscek, McCann, NIOSH (National Institute for Occupational Safety and Health), Oettel, Ostergaard, Prival, Radio, SCF (Scentific Committee on Food), Scotter, Simon, Supramaniam, TemaNord, Viola, Worm, Young   +38 more
core   +2 more sources

Flurochloridone induces responses of free radical reactions and energy metabolism disorders to BRL-3A cell

Ecotoxicology and Environmental Safety, 2022
Flurochloridone (FLC), a wildly used herbicide, could induce hepatotoxicity after long-term exposure to male rat, in addition to its reactive oxygen species (ROS)-dependent reproductive toxicity.
Liming Xue, Jiale Xu, Chao Feng, Zhijun Zhou, Yu’e Jin, Dasheng Lu, Guoquan Wang   +6 more
doaj   +1 more source

Study of Acute Toxicity of a New Veterinary Drug for Inttrammary Introduction [PDF]

, 2018
Preclinical studies of veterinary medicinal products are important and compulsory studies in the development of new dosage forms. The aim of preclinical research is to determine the toxic effect and therapeutic efficacy of the test substance-the future ...
Polova, Z. (Zhanna)
core  

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

UREMIC TOXICITY [PDF]

Nephrology Dialysis Transplantation, 2014
International ...
Hage, V., Pelletier, S., Dubourg, L., Drai, J., Cuerq, C., Lemoine, Sandrine, Hadj-Aissa, A., Laville, M., Fouque, Denis, Chinnappa, S., Tan, L. B., Mooney, A., El Nahas, A. M., Glorieux, G., Vanholder, R., White, E., Jankowski, J., Janke, D., Ruth, M., Lemke, H. D., Jankowski, V., Troeger, T., Wessely, M., Bidlingmaier, M., Schonermarck, U., Hadjamu, N., Rau, S., Fischereder, M., Kim, Y., Hong, Y. A., Kim, M. Y., Lim, J. H., Chang, Y. S., Park, C. W.   +33 more
openaire   +2 more sources

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins [PDF]

, 2014
An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is driven by the repeat RNA itself and/or by dipeptide repeat proteins ...
Cabecinha, M, Clayton, EL, Cleverley, K, Devoy, A, Dols, J, Fisher, EMC, Fratta, P, Grönke, S, Hendrich, O, Isaacs, AM, Mizielinska, S, Moens, T, Niccoli, T, Nicoll, AJ, Norona, FE, Partridge, L, Pickering-Brown, S, Pietrzyk, J, Ridler, CE, Woollacott, IOC   +19 more
core   +1 more source