Results 21 to 30 of about 2,541,601 (314)

Oxidative damage in metal fragment-embedded Sprague-Dawley rat gastrocnemius muscle

Current Research in Toxicology, 2022
Injuries suffered in armed conflicts often result in wounds with embedded metal fragments. Standard surgical guidance has been to leave fragments in place except under certain circumstances; meaning that individuals may carry these retained fragments for
John F. Kalinich, Vernieda B. Vergara, Jessica F. Hoffman   +2 more
doaj   +1 more source

High dose rate brachytherapy as monotherapy for localised prostate cancer : a hypofractionated two-implant approach in 351 consecutive patients [PDF]

, 2013
BACKGROUND: To report the clinical outcome of high dose rate brachytherapy as sole treatment for clinically localised prostate cancer. METHODS: Between March 2004 and January 2008, a total of 351 consecutive patients with clinically localised prostate ...
Baltas, Dimos, Chatzikonstantinou, Georgios, Milickovic, Natasa, Ratka, Markus, Tselis, Nikolaos, Tunn, Ulf W., Zamboglou, Nikolaos   +6 more
core   +1 more source

Impact of Spray Interval and Alternation on Pepper Anthracnose Control: Potential of Chlorothalonil-Based Strategies [PDF]

Research in Plant Disease
Pepper anthracnose, caused predominantly by Colletotrichum scovillei, is one of the most economically significant diseases affecting Capsicum annuum cultivation in Korea.
Hyunjun Lee, Soonsung Hong, Byeongchul Moon, Minju Kim, Gyungmin Lee, Youngsig Lee, Jaedeuk Kim   +6 more
doaj   +1 more source

Transcriptome Analysis of Thiram-Treated Zebrafish (Danio rerio) Embryos Reveals Disruption of Reproduction Signaling Pathways

Biology, 2023
Thiram, a dithiocarbamate fungicide, is used for the treatment of various fungal infections affecting crops and ornamentals. However, thiram-associated toxicity has been reported in animals, including fish, and the underlying molecular mechanisms are ...
Bala Murali Krishna Vasamsetti, Kyongmi Chon, Ji-Yeong Choi, Juyeong Kim, Chang-Young Yoon   +4 more
doaj   +1 more source

Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells [PDF]

, 2010
The small molecule 4-hydroxy-3-methoxybenzaldehyde (5,6,7,8-tetrahydro[1]benzothieno[2,3- d]pyrimidin-4-yl)hydrazone (Exo2) stimulates morphological changes at the mammalian Golgi and trans-Golgi network that are virtually indistinguishable from those ...
Barr, Bock, David J. Stephens, Derby, Doherty, Erickson, Falnes, Feng, Feng, Fiebiger, Frédéric Boal, Fuchs, Gewald, Girod, Guetzoyan, Guy J. Clarkson, Helms, Herold, Hey, Hill, J. Michael Lord, Jackson, Johannes, Johannes, Johannes, Klausner, Lieu, Linstedt, Lu, Lucie J. Guetzoyan, Lynne M. Roberts, Macia, McKenzie, Monier, Nambiar, Nieland, Pavelka, Pelish, Perez-Victoria, Peyroche, Pirali, Plourde, Ponnambalam, Renault, Robert A. Spooner, Rostovtsev, Saenz, Saenz, Sandvig, Shima, Shin, Shin, Spooner, Spooner, Stechmann, Tai, Tsai, Viaud, Volpicelli-Daley, Wells, White, Wilcke, Yarrow, Yoshino, Zeghouf, Zhang, Zhao, Zolov   +67 more
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5-Fluorouracil degradation rate as a predictive biomarker of toxicity in breast cancer patients treated with capecitabine [PDF]

, 2020
Capecitabine is an oral prodrug of 5-fluorouracil with a relevant role in the treatment of breast cancer. Severe and unexpected toxicities related to capecitabine are not rare, and the identification of biomarkers is challenging.
Botticelli, A., Cerbelli, B., Lionetto, L., Marchetti, P., Roberto, M., Scagnoli, S., Simmaco, M.   +6 more
core   +1 more source

A comprehensive method for determination of 55 traditional and emerging per- and polyfluoroalkyl substances in infant complementary foods using liquid chromatography-high resolution mass spectrometry

环境与职业医学
BackgroundPer- and polyfluoroalkyl substances (PFASs) are a class of persistent organic pollutants that pose potential health risks to humans. Infants and young children have higher requirements for food safety due to the underdeveloped detoxification ...
Ziwei LIANG, Chao FENG, Jiawen YOU, Zixin QIAN, Sunyang LE, Dasheng LU   +5 more
doaj   +1 more source

Overexpression of lncRNA IGFBP4–1 reprograms energy metabolism to promote lung cancer progression

Molecular Cancer, 2017
Background Reprogrammed energy metabolism as an emerging hallmark of cancer has recently drawn special attention since it facilitate cell growth and proliferation.
Binyao Yang, Lisha Zhang, Yi Cao, Shuai Chen, Jun Cao, Di Wu, Jiansong Chen, Huali Xiong, Zihua Pan, Fuman Qiu, Jinbin Chen, Xiaoxuan Ling, Maosheng Yan, Suli Huang, Shiyu Zhou, Tiegang Li, Lei Yang, Yunchao Huang, Jiachun Lu   +18 more
doaj   +1 more source

Resveratrol Alleviates Fumonisin B1-Induced Cytotoxicity in Sertoli Cells

Foods
Fumonisin B1 is a common food contaminant that has been found to adversely affect the reproductive system, especially Sertoli cells. However, the potential mitigation of FB1-induced cytotoxicity in Sertoli cells has not been fully elaborated. Resveratrol
Song Yu, Lianpeng Zou, Jiawei Zhao, Yiping Zhu   +3 more
doaj   +1 more source

NQO2 is a reactive oxygen species generating off-target for acetaminophen [PDF]

, 2014
[Image: see text] The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs worldwide. Acetaminophen overdose is also the most common cause for acute liver toxicity.
Ahn K. S., Andersson D. A., Antoine M., Bajt M. L., Bantscheff M., Bessems J. G., Buryanovskyy L., Celli C. M., Cheung C., Chung C. W., Cohen S. D., Cover C., Dahlin D. C., Forman H. J., Fu Y., Graham G. G., Graves P. R., Jaeschke H., James L. P., James L. P., Janbaz K. H., Kheradpezhouh E., Knight T. R., Knox R. J., Laukkanen M. O., Liao S., Lister C. F., Long D. J., Manyike P. T., Martinez Molina D., McGill M. R., Miettinen T. P., Mikael Björklund, Moore M., Moynihan R., Niesen F. H., Nosjean O., Reybier K., Sener G., Shah A. D., Shuhendler A. J., Teemu P. Miettinen, Tirmenstein M. A., Tripathy D., Vella F., Winger J. A.   +45 more
core   +4 more sources