Results 201 to 210 of about 384,674 (248)
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Toxicity Profile of Epichlorohydrin
Journal of Pharmaceutical Sciences, 1972A series of tests was conducted to obtain a profile of the toxicity of epichlorohydrin since this compound finds a number of industrial applications, including synthesis of some epoxy resins which may be formulated into certain biomedical materials. These included acute toxicity by the oral, intraperitoneal, dermal, and inhalation routes; toxicity to ...
W H Lawrence, J E Turner, J Autian
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The Lancet, 2012
2338 www.thelancet.com Vol 379 June 23, 2012 that used data sources very diff erent from ours. At the National Confi dential Inquiry, we collect individual-level suicide data from clinicians as well as data from providers of mental health services. We make every eff ort to make our data available through reports and regular updates on our website. This
J Elisabeth, Wells +2 more
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2338 www.thelancet.com Vol 379 June 23, 2012 that used data sources very diff erent from ours. At the National Confi dential Inquiry, we collect individual-level suicide data from clinicians as well as data from providers of mental health services. We make every eff ort to make our data available through reports and regular updates on our website. This
J Elisabeth, Wells +2 more
openaire +2 more sources
Toxicity profiles of immunotherapy
Pharmacology & Therapeutics, 2018Immunotherapies are changing the landscape of advanced solid tumor treatment. These therapies have different mechanisms of action and include oncolytic viruses, checkpoint inhibitors, such as CTLA-4 or PD1/PD-L1 monoclonal antibodies, and CSF-1R antibodies.
S, Cousin, J, Seneschal, A, Italiano
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Toxicity Profile of Chloroacetaldehyde
Journal of Pharmaceutical Sciences, 1972Chloroacetaldehyde, a probable metabolite of 2-chloroethanol (ethylene chlorohydrin), was studied in a number of in vivo animal systems, in in vitro hemolysis tests, and in tissue cultures to obtain a toxicity profile of the compound. Acute toxicity tests were conducted in mice, rats, guinea pigs, and rabbits by one or more routes of administration ...
W H, Lawrence +3 more
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Preclinical toxicity profile of oral bilastine
Drug and Chemical Toxicology, 2012As part of the bilastine development program, and as mandated by regulatory authorities, several studies were performed with oral bilastine in different animal species to evaluate its toxicity profile. Toxicokinetic analyses conducted in tandem to evaluate systemic exposure, gender differences, and dose proportionality in the different animal species ...
María Luisa, Lucero +3 more
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A Toxicity Profile of Osteoprotegerin in the Cynomolgus Monkey
International Journal of Toxicology, 2003Osteoprotegerin (OPG) is a novel secreted glycoprotein of the tumor necrosis factor (TNF) receptor superfamily that acts as an antiresorptive agent inhibiting osteoclast maturation. OPG acts by competitively inhibiting the association of the OPG ligand with the RANK receptor on osteoclasts and osteoclast precursors.
Brenda B, Smith +7 more
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Safety and toxicity profile of aztreonam
The Pediatric Infectious Disease Journal, 1989Aztreonam is the first monocyclic beta-lactam antibiotic released for clinical use. Extensive toxicity and safety data for aztreonam in animals, healthy volunteers and adult patients have been accumulated previously; recently these studies have been extended to children. Overall the incidence of adverse clinical reactions caused by aztreonam is similar
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Cellular toxicity profile of a new ophthalmic sponge
Cutaneous and Ocular Toxicology, 2023Introduction: Ophthalmic sponges are used for cleaning the eye surface and absorbing fluids during ophthalmic procedures. This study compared the biological safety and stability of a new ophthalmic sponge, Occucell® (OccuTech Inc, Seongnam, Korea), on the human conjunctival epithelial cells with those of preexisting products to evaluate its clinical ...
Keon Woo, Park +5 more
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