Results 211 to 220 of about 384,674 (248)

Norcantharidin toxicity profile: an in vivo murine study

Naunyn-Schmiedeberg's Archives of Pharmacology, 2022
Norcantharidin (NCTD) is the demethylated analog of cantharidin, with allegedly reduced toxicity. However, there is still limited information regarding its posology and potential risk in its use in cancer treatment. Healthy BDF1 mice were intraperitoneally administered with norcantharidin (0, 3, 6, 12, and 25 mg/kg) every 24 h for 6 days. Survivor mice
Gabriel Martínez-Razo, María Lilia Domínguez-López, José M. de la Rosa, Diego A. Fabila-Bustos, Elba Reyes-Maldonado, Eliezer Conde-Vázquez, Armando Vega-López   +6 more
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Discriminating Toxicant Classes by Mode of Action - 1. (Eco)toxicity Profiles

Environmental Science and Pollution Research - International, 2005
Predictive toxicology, particularly quantitative structure-activity relationships (QSARs), require classification of chemicals by mode of action (MOA). MOA is, however, not a constant property of a compound but it varies between species and may change with concentration and duration of exposure.
Monika, Nendza, Andrea, Wenzel
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Linking toxicity profiles to pollutants in sludge and sediments

Journal of Hazardous Materials, 2017
Obtaining a complex picture of how pollutants synergistically influence toxicity of a system requires statistical correlation of chemical and ecotoxicological data. In this study, we determined concentrations of eight potentially toxic metals (PTMs) and four groups of organic pollutants in 15 sewage sludge and 12 river sediment samples, then linked ...
Stiborova, Hana, Kolar, Michal, Vrkoslavova, Jana, Pulkrabova, Jana, Hajslova, Jana, Demnerova, Katerina, Uhlik, Ondrej   +6 more
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Toxicity profiles of vinyl and polyolefinic plastics and their additives

Journal of Biomedical Materials Research, 1968
AbstractThis paper reports on three investigations into the toxic potential of plastics, resins and addivtives, with emphasis on those having medical, dental, or pharmaceutical application. The following points were noted: (1) two different lots of PVC resin contained toxic material which was leachable into a biological system and an extreme ...
W L, Guess, S, Haberman
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Metabolic Profiling as a Tool for Understanding Mechanisms of Toxicity

Toxicologic Pathology, 2008
Metabolic profiling (metabolomics/metabonomics) is the measurement in biological systems of the complement of low-molecular-weight metabolites and their intermediates that reflects the dynamic response to genetic modification and physiological, pathophysiological, and/or developmental stimuli.
Christopher J, Clarke, John N, Haselden
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Molecular Profiling and Prediction of Toxicity

Alternatives to Laboratory Animals, 2001
The rapid progress in genomics and proteomics technologies creates a unique opportunity for understanding the mechanisms of action and the toxicities of compounds. The application of gene-expression and protein-expression profiling promises to improve the predictive power of safety assessment, resulting in the development of drug candidates with a ...
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Green Chromatographic Assay of Toxic Impurities of Cyproheptadine: In Silico Toxicity Profiling

Journal of Chromatographic Science
Abstract Cyproheptadine (CYP) is an antihistaminic and anti-serotonin drug used to improve the clinical course of hospitalized patients severely affected by COVID-19 and requiring supplemental oxygen. Thin layer chromatography (TLC)-densitometry method was developed and validated for the estimation of CYP and its impurity ...
Raghda A Emam, Aml A Emam
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Phytochemical profiling and toxicity assessment of Yinaoxin granules

Journal of Ethnopharmacology
Yinaoxin granules (YNX) is a widely used Chinese herbal preparation composed of six medicinal herbs. YNX has been shown to effectively mitigate both headaches and dizziness. However, systematic investigations into its chemical basis and safety profile remain limited.
Lang Liu, Jingyu Weng, Lei Yue, Yuanyuan Qin, Jia Yu, Yaqi Li, Qian Yang, Shuming Li, Jiaofeng Wu, Yuangui Yang, Zhishu Tang, Hongbo Xu   +11 more
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Genomic and proteomic profiling for biomarkers and signature profiles of toxicity.

Current opinion in molecular therapeutics, 2005
Toxicity profiling measures and compares all gene expression changes among biological samples after toxicant exposure. Toxicity profiling with DNA microarrays to measure all mRNA transcripts (transcriptomics), or by global separation and identification of proteins (proteomics), has led to the discovery of better descriptors of toxicity, toxicant ...
B Alex, Merrick, Maribel E, Bruno
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Liquid automatic dishwashing detergents: A profile of toxicity

Annals of Emergency Medicine, 1989
The recent introduction of liquid automatic dishwashing detergents (LADDs) has resulted in numerous calls to poison information centers and, subsequently, a large number of referrals to emergency departments. As with their traditional granular counterparts, LADDs contain alkaline builders that contribute to the pH of these products.
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