Results 91 to 100 of about 1,013,834 (330)

RESULTS OF PRECLINICAL SAFETY TESTING COMPARISON FOR IBUPROFEN DRUG PRODUCTS

Разработка и регистрация лекарственных средств, 2019
The article contains materials, methods and results of preclinical experimental test of acute toxicity of drugs «Ibuprofen», suspension for oral administration [for children], LP 001651 from 13.04.2012 and referent «Nurofen for children», suspension for ...
E. A. Sitnikova, S. G. Mardanly, E. P. Rogozhnikova   +2 more
doaj  

Proton beam therapy delivered using pencil beam scanning vs. passive scattering/uniform scanning for localized prostate cancer: Comparative toxicity analysis of PCG 001-09

Clinical and Translational Radiation Oncology, 2019
Background and purpose: Patient-level benefits of proton beam therapy (PBT) relative to photon therapy for prostate cancer (PC) continue to be the focus of debate. Although trials comparing the two modalities are underway, most are being conducted using “
Mark V. Mishra, Rahul Khairnar, Søren M. Bentzen, Gary Larson, Henry Tsai, Christopher Sinesi, Carlos Vargas, George Laramore, Carl Rossi, Lane Rosen, Mingyao Zhu, William Hartsell   +11 more
doaj   +1 more source

Evaluating health risks from occupational exposure to pesticides and the regulatory response. [PDF]

, 1994
In this study, we used measurements of occupational exposures to pesticides in agriculture to evaluate health risks and analyzed how the federal regulatory program is addressing these risks.
Bois, FY, Kyle, AD, Woodruff, TJ
core   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Penelitian Toksisitas Daun Stevia Rebaudiana Bertonii M Pada Mencit Dan Tikus Putih [PDF]

, 1985
The acute and subchronic toxicity tests were carried out on the aquaous extract of the leaves of Stevia rebaudiana Bertonii M. obtained from the Balai Penelitian Tanaman Obat in Tawamangu, Surakarta, Central Java.
Budiarso, I. T. (Iwan), J, H. (Hutapea), Wahjoedi, B. (B)   +2 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Acute fish toxicity testing in pesticide risk assessment: still a necessary requirement for the future?

Environmental Sciences Europe
Background The reliance on traditional acute fish toxicity testing in the environmental risk assessment (ERA) of plant protection products (PPPs) raises ethical and scientific concerns, particularly considering the EU’s commitment to the 3Rs principle ...
Elena Adams, Sarah Hartmann, Daniel Faber, Yvonne Wolf, Markus Ebeling, Eric Bruns   +5 more
doaj   +1 more source

Toxicological assessment of the hydroethanolic leaf extract of ''Clerodendrum capitatum'' in Wistar rats

The Pan African Medical Journal, 2016
INTRODUCTION: ''Clerodendrum capitatum''(Willd) Schumach. and Thonn (Lamiaceae) is used in African traditional medicine for the treatment of malaria, hypertension, obesity, jaundice and diabetes however there is lack of experimental data on its possible ...
Kokou Idoh, Amegnona Agbonon, Yao Potchoo, Messanvi Gbeassor   +3 more
doaj   +1 more source

Effects of BPA in snails : Oehlmann et al. respond [PDF]

, 2006
We welcome critical appraisals that help to provide balance; however, Dietrich et al. gave an unjustified reproach. We feel that Dietrich’s position is severely compromised because he serves as an expert for the bisphenol A (BPA) Industry Group (Brussels,
Bachmann, Jean, Kloas, Werner, Lutz, Ilka, Oehlmann, Jörg, Oetken, Matthias, Schulte-Oehlmann, Ulrike, Ternes, Thomas A.   +6 more
core   +2 more sources