Results 231 to 240 of about 960,647 (282)

Strategic hierarchical approaches to acute toxicity testing

Toxicology in Vitro, 1994
Acute toxicity testing, including testing for irritation and sensitization, traditionally has relied heavily on animal models. While this situation has not yet changed dramatically, new developments and approaches offer opportunities to minimize or ultimately to eliminate altogether the use of animals in specific areas of acute toxicity. The value of a
openaire   +2 more sources

Safety evaluation of mulberry leaf extract: Acute, subacute toxicity and genotoxicity studies

Regulatory toxicology and pharmacology : RTP, 2018
Mulberry (Morus alba L.) leaves are of broad popular use for food or remedy purposes due to their bioactive properties, especially antidiabetic activity and antioxidative activity.
Yuzhe Li, Xiaopeng Zhang, Chunlai Liang, Jing Hu, Zhou Yu   +4 more
semanticscholar   +1 more source

Mixture Toxicity Indices in acute lethal toxicity tests

Archives of Environmental Contamination and Toxicology, 1987
The use of Mixture Toxicity Indices (MTI's) is one of the more attractive approaches for describing and predicting the effects of mixtures of toxicants. For an MTI to apply to all possible mixtures of the compounds in question, it must summarize information from a model describing all possible responses of interest.
openaire   +1 more source

Acute toxicity tests and meta‐analysis identify gaps in tropical ecotoxicology for amphibians

Environmental Toxicology and Chemistry, 2014
S. Ghose, M. A. Donnelly, J. Kerby, S. Whitfield   +3 more
semanticscholar   +1 more source

Use of fish embryo toxicity tests for the prediction of acute fish toxicity to chemicals

Environmental Toxicology and Chemistry, 2013
S. Belanger, J. Rawlings, Gregory J. Carr   +2 more
semanticscholar   +1 more source

Standardized methods for acute and semichronic toxicity tests with the copepod Acartia tonsa

Environmental Toxicology and Chemistry, 2012
G. Gorbi, M. Invidia, F. Savorelli, Olga Faraponova, E. Giacco, M. Cigar, I. Buttino, T. Leoni, E. Prato, I. Lacchetti, S. Sei   +10 more
semanticscholar   +1 more source

Acute systemic toxicity—prospects for tiered testing strategies

Toxicology in Vitro, 2004
After many years of controversy and debate, the LD50 test was finally deleted by the end of 2002. Three alternative animal tests, the Fixed Dose Procedure, the Acute Toxic Class Method and the Up and Down Procedure have been developed which give rise to significant improvements in animal welfare.
openaire   +2 more sources

Evaluation of the use of human Mesenchymal Stem Cells for acute toxicity tests.

Toxicology in Vitro, 2011
M. Scanu, L. Mancuso, Giacomo Cao
semanticscholar   +1 more source

Industrial Uses of Acute Toxicity Testing

1986
Several thousand new chemicals are synthesised each year, many of which will add to those already used in commerce. There is both a moral and legal Obligation on the chemical industry to ensure that the risk of adverse effects to human health and the environment is minimal in order to competently satisfy society’s rightful demands for safety. Generally,
openaire   +1 more source

Neutral Red Uptake Cytotoxicity Tests for Estimating Starting Doses for Acute Oral Toxicity Tests

Current Protocols in Toxicology, 2008
W. Stokes, S. Casati, J. Strickland, Michael Paris   +3 more
semanticscholar   +1 more source