Results 41 to 50 of about 960,647 (282)

Acute and sub-acute toxicity evaluation of dihydro-p-coumaric acid isolated from leaves of Tithonia diversifolia Hemsl. A. Gray in BALB/c mice

Frontiers in Pharmacology, 2022
In present study, the acute and sub-acute toxicities of Dihydro-p-coumaric acid isolated from the leaves of Tithonia diversifolia (Hemsl.) A. Gray was studied for safety issues in mammals.
Thiyam B. Devi, Thiyam B. Devi, Sarita Jena, Biswajit Patra, Kabrambam D. Singh, Saurabh Chawla, Vishakha Raina, Arunkumar Singh Koijam, Ajay Parida, Yallappa Rajashekar   +9 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The study of acute toxicity of burdock root tincture

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2014
Aim. Burdock root is used in scientific medicine as diuretic, choleretic, antipyretic, anti-inflammatory, antibacterial, antifungal, desensitizing, immunostimulatory, antioxidant and metabolism improving remedy.
T. V. Оproshanska
doaj   +1 more source

A retrospective analysis of honey bee (Apis mellifera) pesticide toxicity data.

PLoS ONE, 2022
Current USEPA ecological risk assessments for pesticide registration include a determination of potential risks to bees. Toxicity data are submitted to support these assessments and the USEPA maintains a large database containing acute and chronic ...
Frank T Farruggia, Kristina Garber, Christine Hartless, Kristin Jones, Lee Kyle, Nicholas Mastrota, Joseph P Milone, Sujatha Sankula, Keith Sappington, Katherine Stebbins, Thomas Steeger, Holly Summers, Pamela G Thompson, Michael Wagman   +13 more
doaj   +1 more source

ACUTE TOXICITY TEST IN AQUACULTURE: A REVIEW

Banat's Journal of Biotechnology, 2013
Acute toxicity test involves estimation of LC50 or LD50 which is the concentration or dose which proved to be lethal causing death to 50% of the tested organisms. This article reviews the methods utilized for the determination of Probit and LC50 and also explain the use of Minitab 14 statistical package and Microsoft office excel 2007 for accurate ...
Okomoda, V.T., Solomon, S.G., Ataguba, G.A., Ayuba, V.O., Asuwaju, F.P.   +4 more
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Integrated neurobehavioral and organ-specific safety profiling of baicalin: acute/subacute toxicity studies

Frontiers in Pharmacology
Ethnopharmacological relevanceBaicalin, an extract derived from the dried root of Scutellaria baicalensis Georgi (Huang Qin), has demonstrated neuroprotective properties.
Jiali Yang, Jiali Yang, Jiali Yang, Mengyu Chen, Mengyu Chen, Mengyu Chen, Mengyu Chen, Wan Zhang, Wan Zhang, Jia Liu, Jia Liu, Jing Zhao, Jing Zhao, Xin Ping, Xin Ping, Xin Ping, Ye Lu, Ye Lu, Pei He, Pei He, Lin Pei, Lin Pei, Lin Pei, Lin Pei   +23 more
doaj   +1 more source

A permeability test for acute corneal toxicity

Toxicology Letters, 1986
The penetration of sulforhodamine B (SRB) into the two corneas of a freshly killed mouse was measured after one eye was briefly exposed to a solution of a possibly toxic substance. The ratio of the penetrations provides a numerical index of acute toxicity to the corneal epithelium. With a group of 6 animals, a 50% rise in the index can be distinguished
D, Maurice, T, Singh
openaire   +2 more sources

Acute Oral Toxicity

Biology Engineering Medicine and Science Reports, 2019
I am covering this simple and mundane acute toxicity test to increase the awareness, understanding and an appreciation of acute toxicity test, which has undergone sea-change in the last decade.
K. S. Rao
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source