Results 51 to 60 of about 960,647 (282)
Data in Brief, 2018 Toxicity of Municipal Wastewater Treatment Plant Effluent (MWWTPE) was evaluated using bioassay with Daphnia Magna (D. Magna). Acute toxicity tests were performed on effluent samples of Urmia municipal wastewater treatment plant (Biolac system) according
Fathollah Gholami-Borujeni +2 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Scientia Marina, 2004 The sediment formed by the tailings of an abandoned mine, which discharged into Portmán Bay, Murcia, SE-Spain, was tested to establish a possible gradient of heavy metals.
A. Cesar +3 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Ecotoxicological assessment of four pharmaceuticals compounds through acute toxicity tests
O Mundo da Saúde, 2014 In this study, we evaluated acute toxicity of four different pharmaceutical compounds: 17 α-ethinylestradiol (EE2), fluoxetine, diclofenac and ibuprofen to Daphnia similis. The average values of EC50 were 1.63 mg/L to the 17α-ethinylestradiol (EE2), 4.41
Flávia Junqueira de Castro +6 more
doaj
Safety Evaluation of Peony Protein
Shipin gongye ke-jiThis study aimed to assess the safety and toxicity of peony protein and provide a scientific basis for its application in food industry. The safety evaluation included acute oral toxicity tests in mice, as well as 28 d and 90 d oral toxicity tests in ...
Jie LU +5 more
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On the possibility of using biological toxicity tests to monitor the work of wastewater treatment plants [PDF]
Archives of Biological Sciences, 2008 The aim of this study was to ascertain the possibility of using biological toxicity tests to monitor influent and effluent wastewaters of wastewater treatment plants.
Zorić Jelena, Simić V., Petrović Ana
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source