Results 81 to 90 of about 1,013,834 (330)

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Ecotoxicological assessment of four pharmaceuticals compounds through acute toxicity tests

open access: yesO Mundo da Saúde, 2014
In this study, we evaluated acute toxicity of four different pharmaceutical compounds: 17 α-ethinylestradiol (EE2), fluoxetine, diclofenac and ibuprofen to Daphnia similis. The average values of EC50 were 1.63 mg/L to the 17α-ethinylestradiol (EE2), 4.41
Flávia Junqueira de Castro   +6 more
doaj  

Effects of Diet on Seven-Day Ceriodaphnia dubia Toxicity Tests [PDF]

open access: yes, 1993
Author Institution: Department of Biology, The University of AkronThe purpose of this study was to evaluate the effects of four diets on the results of seven-day Ceriodaphnia dubia toxicity tests.
Cerda, Blas, Olive, John H.
core  

Physiological Effects of Five Different Marine Natural Organic Matters (NOMs) and Three Different Metals (Cu, Pb, Zn) on Early Life Stages of the Blue Mussel (Mytilus galloprovincialis) [PDF]

open access: yes, 2017
Metals are present in aquatic environments as a result of natural and anthropogenic inputs, and may induce toxicity to organisms. One of the main factors that influence this toxicity in fresh water is natural organic matter (NOM) but all NOMs are not the
Basso Jorge, Marianna   +5 more
core   +3 more sources

Acute Oral Toxicity

open access: yesBiology Engineering Medicine and Science Reports, 2019
I am covering this simple and mundane acute toxicity test to increase the awareness, understanding and an appreciation of acute toxicity test, which has undergone sea-change in the last decade.
K. S. Rao
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Toxicity of three comercial tannins to the nuisance invasive species Limnoperna fortunei (Dunker, 1857): implications for control [PDF]

open access: yes, 2011
Adding biocides to water is one strategy to control macrofouling organisms. A natural biocide that helps to prevent/control macrofouling of Limnoperna fortunei (Dunker, 1857) on human installations is one way to minimize environmental impacts of ...
Bulus Rossini, Gustavo Daniel   +2 more
core  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

Chronic toxicity of inhaled thymol in lungs and respiratory tracts in mouse model. [PDF]

open access: yes, 2019
Epinephrine HFA (Primatene® Mist) is a newly formulated asthma metered dose inhaler developed to replace the previous Primatene® Mist CFC. The formulation of Epinephrine HFA contains thymol, a substance recognized to be safe by the FDA.
Luo, Mary Z   +3 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

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