Results 181 to 190 of about 15,678,062 (402)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Uranium from Seawater Program at the Pacific Northwest National Laboratory: Overview of Marine Testing, Adsorbent Characterization, Adsorbent Durability, Adsorbent Toxicity, and Deployment Studies

, 2016
Gary A. Gill, Li‐Jung Kuo, Christopher J. Janke, Jiyeon Park, Robert T. Jeters, George T. Bonheyo, Horng-Bin Pan, Chien M. Wai, Tarang Khangaonkar, Laura Bianucci, Jordana R. Wood, Marvin G. Warner, Sonja Peterson, David G. Abrecht, Richard T. Mayes, Costas Tsouris, Yatsandra Oyola, Jonathan E. Strivens, Nicholas J. Schlafer, R. Shane Addleman, Wilaiwan Chouyyok, Sadananda Das, Jungseung Kim, Ken O. Buesseler, Crystal Breier, Evan K. D’Alessandro   +25 more
openalex   +2 more sources

Free Versus Bound Concentration: Passive Dosing from Polymer Meshes Elucidates Drivers of Toxicity in Aquatic Tests with Benthic Invertebrates

, 2022
Fabian C. Fischer, Kyoshiro Hiki, Satoshi Endo   +2 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The suitability of potworms (<i>Enchytraeidae</i>) and plants to test the toxicity of oil refinery sludge

, 2016
A.J. Reinecke, Sophia A. Reinecke, Mia Van Wyk   +2 more
openalex   +2 more sources

Current Approaches to the Abnormal Toxicity Test

, 2020
Н. П. Неугодова, E. O. Stepanyuk, Г. А. Сапожникова, E. I. Sakanyan, M. S. Ryabtseva   +4 more
openalex   +2 more sources

Evaluation of photosynthetic performance of wheat cultivars exposed to boron toxicity by the JIP fluorescence test [PDF]

, 2014
Mehmet Tufan Öz, Özlem Turan, Ceyhun Kayıhan, Füsun Eyidoğan, Yasemin Ekmekçi, Meral Yücel, Hüseyin Avni Öktem   +6 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Comparison of <i>in vitro</i> (fish cell line) and <i>in vivo</i> (fish and crustacean) acute toxicity tests in aquatic toxicology. [PDF]

Vet Med (Praha), 2021
Kolarova J, Velisek J, Svobodova Z.
europepmc   +1 more source