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Toward High-Throughput Fish Embryo Toxicity Tests in Aquatic Toxicology.

Environmental Science and Technology, 2021
Addressing the shift from classical animal testing to high-throughput in vitro and/or simplified in vivo proxy models has been defined as one of the upcoming challenges in aquatic toxicology. In this regard, the fish embryo toxicity test (FET) has gained
D. Wlodkowic, O. Campana
semanticscholar   +1 more source

Acute Toxicity of a Tire Rubber-Derived Chemical, 6PPD Quinone, to Freshwater Fish and Crustacean Species

Environmental Science and Technology Letters, 2021
N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone, also known as 6PPD quinone, was recently identified as a toxic chemical that causes acute mortality in coho salmon following exposure to urban runoff.
Kyoshiro Hiki   +7 more
semanticscholar   +1 more source

Fish embryo tests and acute fish toxicity tests are interchangeable in the application of the threshold approach

Environmental Toxicology and Chemistry, 2019
A database was compiled for algal Organisation for Economic Co‐operation and Development (OECD) test guideline 201, for Daphnia magna OECD test guideline 202, for the acute fish toxicity (AFT) OECD test guideline 203, and for the fish embryo toxicity ...
J. Rawlings   +3 more
semanticscholar   +1 more source

Chronic Toxicity Testing

Nature, 1965
CERTAIN types of hazard consequent on the administration of chemical substances are estimated by the performance of chronic toxicity tests. Such tests are usually designed according to certain empirical rules. Groups of animals (commonly three) are given a test substance in regularly repeated doses of constant size, each group receiving a different ...
openaire   +2 more sources

Toxicity Testing, Alternatives

2005
Since the early 1980s, public perception of the value of (and benefits from) animal testing has been strongly influenced by what is now called the animal rights movement. This concern has done a great deal of good because it has caused careful consideration of why and how testing is performed, with significant alterations being made in practices across
openaire   +1 more source

Toxicity Testing, Reproductive

2005
Abstract Reproductive toxicity evaluations encompass embryo/fetal development in utero, secondary and tertiary sex characteristics, sexual behavior and performance in both sexes, and pregnancy, parturition, lactation, and other maternal behaviors in females.
openaire   +1 more source

Toxicity Testing

2020
This chapter reviews toxicity testing. The testing of the toxicity profile of a potential drug candidate is a vital component of drug development. Toxicological studies are usually carried out at the same time as other aspects of drug development as, if any significant toxicity problems are detected, further development of the drug can be stopped ...
openaire   +2 more sources

Toxic Tests

The Economists' Voice, 2009
Lucian Bebchuk of Harvard argues that the U.S. stress test for banks was deeply flawed and other countries should at least try to gauge the long term losses on toxic assets.
openaire   +1 more source

Toxicity Testing, Carcinogenesis

2005
Carcinogenicity testing in experimental animals is typically done under conditions that maximize the potential for detecting an effect. The scientific ideal is to evaluate a chemical’s carcinogenic potential from human data. While controlled exposure studies for carcinogenesis are not ethical, information can sometimes be obtained from epidemiology ...
openaire   +1 more source

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