Results 321 to 330 of about 15,678,062 (402)

Toxicity Testing, Sensitization

2005
A variety of assays have been validated for the detection of skin sensitizers. Most of the assays are in vivo assays, which take into account interactions of the complex immune system of animals. Guidelines have been issued for the conduct of a variety of skin sensitization assays.
openaire   +1 more source

Pharmacokinetics and Toxicity Testing

CRC Critical Reviews in Toxicology, 1984
The pharmacokinetic basis for the design of toxicity tests is discussed with reference to the absorption and clearance of drugs. The absorption and clearance of a wide range of drugs by laboratory animals and man has been examined and reviewed to provide a firm basis against which new drugs can be compared.
Bruce Clark, Dennis A. Smith, John Caldwell   +2 more
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Toxicity Testing of Nanomaterials

2012
The large-scale production and consumer exposure to a variety of nanotechnology innovations has stirred interest concerning the health consequences of human exposure to nanomaterials. In order to investigate these questions, in vitro systems are used to rapidly and inexpensively predict the effects of nanomaterials at the cellular level.
Amanda M, Schrand, Liming, Dai, John J, Schlager, Saber M, Hussain   +3 more
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Rethinking guideline toxicity testing

Regulatory Toxicology and Pharmacology, 2015
The guidelines for risk assessment of plant protection products (PPPs) and other non-pharmaceuticals were developed over three decades ago and have generally not been updated to incorporate advancements in toxicology and exposure sciences. These guidelines recommend using maximum-tolerated-dose (MTD) even when human relevance of such high doses is ...
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Physiological endpoints in daphnid acute toxicity tests.

Science of the Total Environment, 2020
A. Bownik
semanticscholar   +1 more source

Autoimmunity and toxicity testing

Toxicology Letters, 2000
Major difficulties when addressing autoimmunity today within the context of regulatory toxicology are the following: (i) the incidence of auto-immunity related to chemical exposure is not known; (ii) the mechanisms involved are not understood in most instances; and (iii) no fully validated models are available.
openaire   +2 more sources

Automated Lab-on-a-Chip Technology for Fish Embryo Toxicity Tests Performed under Continuous Microperfusion (μFET).

Environmental Science and Technology, 2015
F. Zhu, Adriana Wigh, Timo Friedrich, A. Devaux, S. Bony, D. Nugegoda, J. Kaslin, D. Wlodkowic   +7 more
semanticscholar   +1 more source

Application of simple and low-cost toxicity tests for ecotoxicological assessment of industrial wastewaters

Environmental technology, 2015
M. Aydin, S. Aydın, Süheyla Tongur, G. Kara, M. Kolb, M. Bahadir   +5 more
semanticscholar   +1 more source

Guidance for improving comparability and relevance of oil toxicity tests.

Marine Pollution Bulletin, 2015
A. Redman, T. Parkerton
semanticscholar   +1 more source

Temporal changes in the sensitivity of coastal Antarctic zooplankton communities to diesel fuel: A comparison between single‐ and multi‐species toxicity tests

Environmental Toxicology and Chemistry, 2014
Sarah Payne, C. King, L. M. Zamora, P. Virtue   +3 more
semanticscholar   +1 more source