Results 51 to 60 of about 435,111 (310)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Research advances in applications of reproductive toxicity alternative tests in safety evaluation of traditional Chinese medicines

, 2021
The application of traditional Chinese medicines (TCMs) has a long history. However, most of TCMs, even "toxic medicines", have not had their safety evaluated before being applied to humans.
Lei, Xia Ling, Guo, Jian Min, Han, Ling, Liu, Lu, Yang, Wei, Chen, Wen Pei   +5 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Ecotoxicity test methods for engineered nanomaterials: Practical experiences and recommendations from the bench

, 2011
Ecotoxicology research is using many methods for engineered nanomaterials (ENMs), but the collective experience from researchers has not been documented.
Tara Sabo-Attwood, Jeffery A. Steevens, Cornelis, Geert, Cornelis, G., Chris Metcalfe, Stephen J. Klaine, Metcalfe, Chris, Alan Decho, Fernandes, Teresa, Tsyusko, O., Horne, Nina, Sabo-Attwood, T., Metcalfe, C., Steevens, Jeffery, Decho, A., Handy, Richard D., Decho, Alan, Steevens, J.A., Koelmans, A.A., Decho, Alan W., Teresa Fernandes, Olga Tsyusko, Nina Horne, Tsyusko, Olga, Albert A. Koelmans, Sabo-Attwood, Tara, Fernandes, T., Klaine, Stephen J., Geert Cornelis, Klaine, S.J., Horne, N., Richard D. Handy, Koelmans, Albert A., Fernandes, Teresa; id_orcid, Handy, R., Fernandes, Teresa F., Steevens, Jeffery A., Stevens, Jeffery A.   +37 more
core   +1 more source

Evaluation of toxicity from leachate lagoons sediments, using the toxicity leaching procedure - TCLP and acute toxicity tests

Dyna, 2019
Landfills have been the most used alternative for final municipal solid wastes disposal, however, this system is the responsible of contamination problems associated with the generation of leachates, sediments and toxic gasses emissions.
Patricia Torres Lozada, Yazmin Carabalí Rivera, Luz Edith Barba Ho   +2 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Safety Assessment of a New Strain of Lactobacillus pentosus (IBRC=11143) as a Candidate Probiotic

Pharmaceutical and Biomedical Research, 2020
Background: It is believed that the consumption of an adequate amount of live lactic acid bacteria (as probiotic) may improve the health of the host. Many strains of lactic acid bacteria are generally considered to be safe.
Saba Bahrehvar, Shiva Khezri , Vahid Nejati, Amir Abbas Barzegari   +3 more
doaj  

Guanicid and PHMG Toxicity Tests on Aquatic Organisms

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2016
The emergence and development of new algicidal products is caused by the ever increasing popularity of garden ponds as well as the use of these products in the fisheries sector, especially for disposal of cyanobacteria and algae.
Eva Poštulková, Radovan Kopp
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Developing a Passive Dosing Method for Acute Aquatic Toxicity Tests of Cationic Surfactant Benzalkoniums (BACs)

Benzalkonium chlorides (BACs) have been of environmental concern due to their widespread use and potential harm. However, challenges arise in defining and controlling the exposure concentration (Cw) in aquatic toxicity tests involving BACs with a long ...
Hiroshi, Yamamoto, Kyoshiro, Hiki, Satoshi, Endo, Anh T.Ngoc, Do, Haruna, Watanabe   +4 more
core   +1 more source