Results 71 to 80 of about 435,111 (310)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Use of Macroinvertebrate Life History Information in Toxicity Tests
, 1979 Life history information of macroinvertebrates is an important variable to consider when interpreting the results of toxicity tests. The importance of life history information has been recognized in the culturing of macroinvertebrates, but only in the ...
Arthur L. Buikema Jr. +1 more
core +1 more source
, 2022 Whole effluent toxicity (WET) testing uses whole animal exposures to assess the toxicity of complex mixtures, like wastewater. These assessments typically include four apical endpoints: mortality, growth, development, and reproduction. In the last decade,
Leusch, Frederic DL +2 more
core +1 more source
Brazilian Journal of Oceanography, 1999 The liquid effluent from an oil maritime terminal, with produced water as the main component, had its toxicity evaluated through toxicity tests with the diatom Skeletonema costatum.
Elizabeth Aidar +5 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Toxicity evaluation and medical application of multi-walled carbon nanotubes [PDF]
, 2015 Carbon nanotubes (CNTs) are of special interest to industry and they have been increasingly utilised as advanced nanovectors in drug/gene delivery systems.
Zhou, Lulu
core
Hepatotoxicity of the phytomedicines Kava Kava and Cimicifuga Racemosa [PDF]
, 2005 In this thesis the hepatotoxic properties of the two phytomedicines kava kava and cimicifuga racemosa have been investigated. This topic is a prevailing problem as herbal medicines are quite popular today and not much is known about their toxicological
Lüde, Saskia
core +1 more source
Ceriodaphnia dubia Chronic Toxicity Tests
, 2009 Crustaceans are considered an important part of the soft water zooplankton community. Therefore they represent water organisms in the test set for the ecotoxicological characterization of wastes. Following ISO/CD guideline 20665, the chronic Ceriodaphnia
P. Pandard +7 more
core +2 more sources