Results 31 to 40 of about 7,208 (144)

A Comprehensive Study to Compare Different Compound Representations for Predicting Carcinogenicity In Vivo

Journal of Applied Toxicology, EarlyView.
ABSTRACT Carcinogenicity evaluation is a critical component of chemical risk assessment, yet traditional in vivo testing remains time consuming, costly, and ethically challenging. Computational approaches based on machine learning offer promising alternatives, but the relative contributions of different molecular representation strategies for ...
Iuri Barbosa Pereira, Rogerio Salvini, Eloisa Dutra Caldas   +2 more
wiley   +1 more source

Dietary impact of agri‐food by‐products on the volatile composition of Tenebrio molitor larvae

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Incorporating Tenebrio molitor larvae as ingredients in common foods is a promising strategy to encourage their consumption. To achieve this, knowing their volatile profile and the factors that may modify the profile is essential. The effect of larval feeding over volatile composition remains under‐researched, for this reason; the ...
María Lourdes Morales, José Raúl Aguilera‐Velázquez, Raquel María Callejón, Juan Bautista, Daniel Gutiérrez‐Praena, Cristina Ubeda   +5 more
wiley   +1 more source

Health Biomarkers of Pesticide Exposure in Rural Populations of Santa Fe, Argentina: Oxidative Stress and Genotoxicity

Journal of Applied Toxicology, Volume 46, Issue 11, Page 3804-3813, November 2026.
ABSTRACT The present study aimed to quantify pesticide residues in environmental matrices and plasma and to evaluate their potential effects on oxidative stress and DNA damage in rural populations of Santa Fe province. Soil and rainwater samples were collected, and biological samples and semistructured surveys were obtained from volunteers in three ...
María Priscila Dechiara, Carlina Leila Colussi, Lucía Magdalena Odetti, Damián Marino, María Fernanda Simoniello   +4 more
wiley   +1 more source

Intoxicação cúprica em ovinos via concentrado e sal mineral: Relato de caso

Pubvet, 2018
O presente relato teve por objetivo descrever o quadro clínico-patológico da intoxicação por cobre em ovinos. A ocorrência mais comum de intoxicação por cobre está relacionada à ingestão de concentrado e suplementos minerais destinados a bovinos.
Daniel Lúcio do Nascimento, Eduardo Alves Lima, Thalita Tainá Ribeiro Faria, Izabela De Assis Rocha, Thais Caroline Botelho De Aguiar, Adriana de Souza Coutinho   +5 more
doaj   +1 more source

Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models

Environmental Toxicology, Volume 41, Issue 10, Page 957-974, October 2026.
ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa, Analía Ale, Azael Francisco Silva Neto, Lorena De Mendonça Lucena, Marcelo Estrella Josende, Milena Ferreira de Lima, Rhayanny Kethylly Pereira Santos, Martín Federico Desimone, Priscila Gubert, José María Monserrat   +9 more
wiley   +1 more source

DNA damage and cytotoxicity in pathology laboratory technicians exposed to organic solvents

Anais da Academia Brasileira de Ciências, 2016
The aim of this study was to evaluate potential DNA damage and cytotoxicity in pathology laboratory technicians exposed to organic solvents, mainly xylene.
TATIANE DE AQUINO, FERNANDA F. ZENKNER, JOEL H. ELLWANGER, DANIEL PRÁ, ALEXANDRE RIEGER   +4 more
doaj   +1 more source

Nonpolar and Polar Lipids Composition in Recombinant Chinese Hamster Ovary Cells by Nile Red Staining Flow Cytometry

European Journal of Lipid Science and Technology, Volume 128, Issue 9, September 2026.
Cellular lipid composition is a dynamic process. Understanding it is important to improve recombinant protein production. Molecules with solvatochromic properties allow the determination of lipids of different polarities by flow cytometry and offer a useful method for monitoring lipids during different phases of cell growth in bioprocesses.
Francisco E. López‐Salas, Enrique García‐Hernández, Francisco Gasteazoro, Emiliano Balderas‐Ramírez, Octavio T. Ramírez, Georgina I. López‐Cortés, Helgi Jung‐Cook, Emilio Rojas, Mauricio A. Trujillo‑Roldán, Norma A. Valdez‑Cruz   +9 more
wiley   +1 more source

Prenatal Stress Induced by Maternal Immune Activation Disrupts GABAergic Inhibition and Mossy Fiber Plasticity in the Rat Dentate Gyrus‐CA3 Circuit

Hippocampus, Volume 36, Issue 5, September 2026.
ABSTRACT Viral infections during critical periods of pregnancy trigger inflammatory responses that alter offspring brain development and behavior, resulting in psychiatric disorder‐associated phenotypes. This condition is commonly referred to as prenatal stress induced by maternal immune activation (MIA).
Johaly Anguiano‐Buenfil, Isabel Sollozo‐Dupont, Luis A. Márquez, Angelica Zepeda, Emilio J. Galván   +4 more
wiley   +1 more source

Classificação de resíduos sólidos industriais com base em testes ecotoxicológicos utilizando Daphnia magna: uma alternativa

Biotemas, 2005
O tratamento e a disposição final adequada dos resíduos sólidos industriais dependem de sua classificação em classe I ou II. Esta classificação é proposta pela NBR 10.004, contudo, é complexa e demanda tempo.
Letícia Flohr, Débora Monteiro Brentano, Cátia Regina Silva de Carvalho-Pinto, Vanessa Guimarães Machado, William Gerson Matias   +4 more
doaj  

Inhibition of kynurenine 3‐monooxygenase (KMO) reduces fentanyl and sucrose intake and relapse‐like behaviour in rats

British Journal of Pharmacology, Volume 183, Issue 18, Page 5458-5475, September 2026.
Abstract Background and Purpose Opioid use disorder, particularly involving fentanyl, poses major challenges due to high relapse rates and limited effectiveness of pharmacotherapies. The kynurenine pathway has emerged as a target for addiction treatment through its modulation of glutamatergic and dopaminergic neurotransmission.
Carlos Núñez‐de la Calle, Lluna Careaga, Stefanie Malan‐Müller, Álvaro del Río‐García, Yaiza Trueba, Leticia Gil de Biedma‐Elduayen, Nuria Morales‐Puerto, Rebeca Vidal, Åsa Wiman, Sophie Erhardt, María Dolores Gutiérrez‐López, Esther O'Shea, María Isabel Colado   +12 more
wiley   +1 more source