Results 121 to 130 of about 22,157,959 (291)

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Remediation of Surfactants Used by VUV/O₃ Techniques: Degradation Efficiency, Pathway and Toxicological Analysis. [PDF]

Molecules, 2023
Li H, Yang Y, Li X, Ullah H.
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Application of Teeth in Toxicological Analysis of Decomposed Cadavers Using a Carbamazepine-Administered Rat Model. [PDF]

Diagnostics (Basel), 2023
Ichioka H, Saito U, Shintani-Ishida K, Shirahase T, Idota N, Kanamura N, Ikegaya H.   +6 more
europepmc   +1 more source

Application of radioreceptor assays for systematic toxicological analysis: 2. Theoretical considerations and evaluation

, 1994
In this paper the applicability ot radioreceptor assays tor systematic toxicological analysis will be evaluated on a theoretical basis as well as on the basis of the outcomes of the analysis of a large number of urine samples collected after ...
Ensing, K., Egberts, A.C.G., de Zeeuw , R.A., de Zeeuw, R.A., Franke, J.P., Bosman, I.   +5 more
core   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

Toxicological profile for 2-hexanone [PDF]

cdc:6178VERSION HISTORYDate DescriptionFebruary 2020 Final toxicological profile releasedApril 2018 Draft for public comment toxicological profile releasedSeptember 1992 Final toxicological profile ...

core   +1 more source

Toxicological Analysis in Tissues Following Exhumation More Than Two Years after Death (948 Days): A Forensic Perspective in a Fatal Case. [PDF]

Toxics, 2023
Albano GD, Zerbo S, La Spina C, Midiri M, Guadagnino D, D'Anna T, Buscemi R, Argo A.   +7 more
europepmc   +1 more source

The Plant‐to‐Plant Circular Strategy: Coupling Photodegradation and Phytoremediation With Plant‐Based Nanomaterials for Plastic Degradation

Advanced Science, EarlyView.
Plant‐based nanomaterials derived from alfalfa serve as dual‐function catalysts, coupling photodegradation and phytoremediation to degrade polyethylene under UV‐A light and in soil. The nanomaterials work synergistically with alfalfa and soil microbes, achieving efficient plastic breakdown without trophic transfer.
Haoran Liu, Lena Ciric, Yuheng Wang, Ziru Pei, Manpreet Bhatti   +4 more
wiley   +1 more source

Molecular Analysis of Escherichia coli and Correlations Between Phylogroups and Sequence Types from Different Sources

Microorganisms
Escherichia coli is a significant pathogen responsible for infections in both humans and livestock, possessing various virulence mechanisms and antimicrobial resistance that make it even more concerning.
João Gabriel Material Soncini, Vanessa Lumi Koga, Bruna Fuga, Zuleica Naomi Tano, Gerson Nakazato, Renata Katsuko Takayama Kobayashi, Nilton Lincopan, Eliana Carolina Vespero   +7 more
doaj   +1 more source