Results 101 to 110 of about 22,157,959 (291)

Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential

Pharmaceuticals
Flavonoids constitute a broad class of naturally occurring chemical compounds classified as polyphenols, widely present in various plants, fruits, and vegetables. They share a common flavone backbone, composed of two aromatic rings (A and B) connected by
Magdalena Kurkiewicz, Aleksandra Moździerz, Anna Rzepecka-Stojko, Jerzy Stojko   +3 more
doaj   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Frequency of Thalassemias in the Brazilian Population and Comparison Between Diagnostic Methods: A Systematic Review

Thalassemia Reports
Thalassemia is an inherited hemoglobin disorder caused by reduced or absent globin chain synthesis, with heterogeneous distribution worldwide and in Brazil. Back-ground/Objectives: This systematic review aimed to estimate the frequency of thalas-semia in
Eliana A. Santos, Luciana S. Wermelinger, Renato S. Carvalho   +2 more
doaj   +1 more source

Gas chromatographic retention indices of solvents and other volatile substances for use in toxicological analysis /

, 1992
It is the first book of its kind that contains data bases for two different types of Carbowax columns, one based primarily on adsorption chromatography, the other on partition chromatography.
International Association of Forensic Toxicologists.Committee for Systematic Toxicological Analysis., de Zeeuw, Rokus A.,, Deutsche Forschungsgemeinschaft.   +2 more
core  

Priority-Setting in the REACH System

, 2006
Due to the large number of chemicals for which toxicological and ecotoxicological information is lacking, priority setting for data acquisition is a major concern in chemicals regulation.
Hansson, Sven Ove,, Rudén, Christina,
core   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

From Traditional Amazon Use to Food Applications: Tapirira guianensis Seed Extracts as a Triad of Antiproliferative Effect, Oxidative Defense, and Antimalarial Activity

Foods
Tapirira guianensis is a tropical plant found in South America and is widely used by indigenous communities owing to its medicinal properties. Its seeds are rich in phenolic compounds that are known for their anti-inflammatory, antioxidant, and ...
Marcell Crispim, Thaise Caputo Silva, Amanda dos Santos Lima, Laura da Silva Cruz, Nathalia Alves Bento, Thiago Mendanha Cruz, Yasmin Stelle, Josiana Moreira Mar, Daniel de Queiroz Rocha, Jaqueline de Araújo Bezerra, Luciana Azevedo   +10 more
doaj   +1 more source

Toxicological Analysis of Intoxications with Synthetic Cathinones. [PDF]

J Anal Toxicol, 2022
Pieprzyca E, Skowronek R, Czekaj P.
europepmc   +1 more source

Toxicological Analysis [PDF]

Journal of Pharmacy and Pharmacology, 1955
openaire   +3 more sources