Results 111 to 120 of about 22,157,959 (291)

Toxicological analysis of opiates from alternative matrices collected from an exhumed body

, 2017
In this case study, the body of a 45-year-old man was exhumed after 1 year at the request of the public prosecutor to assess whether the death was caused by drug consumption.
Dora Mirtella, Giovanni Ottaviani, Giovanna Tassoni, Rino Froldi, Marta Cippitelli, Mariano Cingolani   +5 more
core   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Antibody response induced by structural proteins from Triatoma virus as potential adjuvants in experimental immunisation models

Frontiers in Microbiology
IntroductionVirus-Like Particles (VLPs) are viral protein structures widely used as adjuvants in vaccine formulations due to their ability to stimulate the innate immune response, thereby contributing to the activation of adaptive immunity through the ...
Aline Maria Vasconcelos Queiroz, Aline Maria Vasconcelos Queiroz, Annamairlla do Nascimento Oliveira, Annamairlla do Nascimento Oliveira, Alzira Regina Silva de Deus, Alzira Regina Silva de Deus, Ingrid Emiliane Fonseca de Oliveira, Isaías Amâncio dos Santos, Fred Luciano Neves Santos, Paola Alejandra Fiorani Celedon, Diego M. A. Guérin, Ana Rosa Viguera, Marcelo Sousa-Silva, Marcelo Sousa-Silva, Marcelo Sousa-Silva   +14 more
doaj   +1 more source

Toxicological profile for nitrophenols [PDF]

VERSION HISTORYDate DescriptionApril 2023 Final toxicological profile releasedApril 2022 Draft for public comment toxicological profile releasedJuly 1992 Final toxicological profile releasedtp50 ...

core  

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

Overview of systematic toxicological analysis strategies and their coverage of substances in forensic toxicology. [PDF]

Anal Sci Adv, 2023
Rygaard K, Pan M, Nielsen MKK, Dalsgaard PW, Rasmussen BS, Linnet K.   +5 more
europepmc   +1 more source

Advanced Instrumental Method of Analysis in Analytical Toxicology Laboratory for Toxicological Analysis

International Journal of Pharmaceutical Research and Applications
Major advances in analytical toxicology followed the introduction of spectroscopic and chromatographic techniques. Thin layer chromatography remains important together with some spectrophotometric and other tests. However, gas and high-performance liquid chromatography together with variety of enzyme immunoassay techniques are now widely used. Advanced
Abhijith Jayan Abhijith Jayan, SreeragS SreeragS, Thanuja T Thanuja T, VipinJoseph VipinJoseph, Girish Kumar K Girish Kumar K   +4 more
openaire   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Greener solvents for microelution solid phase extraction of proteins from biological fluids followed by their top-down CE-MS analysis

Advances in Sample Preparation
In recent years, there has been a growing demand for making the analytical processes sustainable and environmentally friendly. In proteomic analysis, sample preparation plays an important role, employing different extraction techniques to isolate ...
Martina Opetová, Radovan Tomašovský, Katarína Maráková   +2 more
doaj   +1 more source

A hyperspectral and toxicological analysis of protein corona impact on silver nanoparticle properties, intracellular modifications, and macrophage activation

, 2015
Jonathan H Shannahan,1 Ramakrishna Podila,2,3 Jared M Brown1 1Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of Colorado Anschutz Medical Campus, Aurora, CO, 2Department of Physics and ...
Brown JM, Shannahan JH, Podila R
core