Results 31 to 40 of about 22,157,959 (291)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Long COVID and Its Impacts: A Case–Control Study in Brazil

Biomedicines
Introduction: Long COVID, or post-COVID-19 syndrome, refers to a set of persistent symptoms following SARS-CoV-2 infection without another identifiable cause.
Cristina M. Ruas, Maria Laura Silva, Ana L. G. F. Figueiredo, Amanda P. de Alencar, Samuel de S. Melo, Geovani F. de Castro, Natália V. Carobin, Melina A. Cordeiro, Janete F. R. Aguirre, Amanda F. M. de Oliveira, Adriano de P. Sabino   +10 more
doaj   +1 more source

Toxicology and Analysis of Psychoactive Tryptamines [PDF]

International Journal of Molecular Sciences, 2020
Our understanding of tryptamines is poor due to the lack of data globally. Tryptamines currently are not part of typical toxicology testing regimens and their contribution to drug overdoses may be underestimated. Although their prevalence was low, it is increasing.
Sara Malaca, Alfredo Fabrizio Lo Faro, Alice Tamborra, Simona Pichini, Francesco Paolo Busardò, Marilyn A. Huestis   +5 more
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Toxicological analysis of acute pesticides poisoning among Moroccan population

, 2021
The aim of this study is to evaluate the importance of toxicological analysis in acute intoxications by pesticides through the experience of the laboratory of the Poison Control and Pharmacovigilance Center of Morocco (CAPM).
Narjis Badrane, Bouchra Birich, Naima Ait Daoud, Rachida Soulaymani Bencheikh, Souad El Hajjaji, Mohamed Ghandi, Mustapha Ouaide   +6 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Circulating levels of sFlt-1 and AT1-AA in women with prior preeclampsia: a 10-year postpartum cross-sectional analysis (PERLA-Brazil study)

Scientific Reports
This study investigated whether soluble fms-like tyrosine kinase-1 (sFlt-1) and angiotensin II type 1 receptor autoantibodies (AT1-AA) – key mediators of preeclampsia (PE) pathophysiology – remain elevated ten years postpartum, thereby contributing to ...
Thaíse Emilia Moreira da Silva, Isabella Macedo Costa, Ana Paula Silva Ferreira, Thays Santos da Costa, Luiza Oliveira Perucci, Juliano Armstrong Arnosti, Luci Maria Sant’Ana Dusse, Jussara Mayrink, Patrícia Nessralla Alpoim   +8 more
doaj   +1 more source

Antibacterial and Antiparasitic Effects of venom

Natural Product Communications, 2012
The therapeutic potential of toxins has aroused great interest in the scientific community. Microbial resistance is a serious current public health problem, in part because of the wide use of antimicrobial drugs.
Ramon R.P.P.B. de Menezes, Alba F. C. Torres, Thiala S. J. da Silva, Daniel F. de Sousa, Danya B. Lima, Dive B. Norjosa, Nádia A. P. Nogueira, Maria F. Oliveira, Márcia R. de Oliveira, Helena S. A. Monteiro, Alice M. C. Martins   +10 more
doaj   +1 more source

Application of metabolomics in toxicological analysis [PDF]

, 2023
The aim of this article was to present the most important aspects of the modern application of metabolomics in toxicology. The information contained herein comes from works that have appeared in recent years in specialist periodicals and publications ...
Hubert Stankowicz, Maciej Tadeusz Gawlik, Izabela Krzemień   +2 more
core   +2 more sources

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source