Results 251 to 260 of about 160,346 (305)

Preclinical toxicology studies with azithromycin: genetic toxicology evaluation

Mutation Research/Genetic Toxicology, 1993
Azithromycin was subjected to a series of three in vitro and one in vivo genetic toxicology assays for the detection of drug-associated gene or chromosomal effects. In the Ames Salmonella typhimurium tester strains TA1535, TA1537, TA98 and TA100, the presence of azithromycin was not associated with any increase in the number of his- revertants.
D E, Amacher, J H, Ellis, A J, Joyce, P A, Muehlbauer, G N, Turner, M G, Wahrenburg, H E, Holden, V A, Ray   +7 more
openaire   +2 more sources

Toxicological Safety Evaluation of Gadobutrol

Investigative Radiology, 2012
Gadobutrol (Gadovist/Gadavist, Bayer Pharma AG, Berlin, Germany) is a nonionic, macrocyclic, gadolinium-based contrast agent for magnetic resonance imaging of the central nervous system as well as liver and kidneys and for contrast enhancement in magnetic resonance angiography. For risk assessment of the single diagnostic use in humans, the toxicity of
Christiane, Wack, Thomas, Steger-Hartmann, Louis, Mylecraine, Rainer, Hofmeister   +3 more
openaire   +2 more sources

Toxicological evaluation of cyclosporin A

Archives of Toxicology, 1983
Toxicological studies in a variety of different animal species have shown that cyclosporin A (CS-A) is a unique immunosuppressant, since it does not cause myelotoxic, teratogenic, mutagenic, or carcinogenic effects. This is undoubtedly due to the fact CS-A produces its immunosuppressive effects by a specific action on T lymphocytes rather than by a ...
B, Ryffel, P, Donatsch, M, Madörin, B E, Matter, G, Rüttimann, H, Schön, R, Stoll, J, Wilson   +7 more
openaire   +2 more sources

Toxicological evaluations of colostrum ultrafiltrate

Regulatory Toxicology and Pharmacology, 2019
Colostrum has been consumed safely for many years as a food collected directly from cows. More recently, an ultrafiltrated bovine colostrum product has been developed; however, its safety in toxicology studies has not been extensively evaluated.
Anne Thiel, Róbert Glávits, Timothy S. Murbach, John R. Endres, Robin Reddeman, Gábor Hirka, Adél Vértesi, Erzsébet Béres, Ilona Pasics Szakonyiné   +8 more
openaire   +2 more sources

Toxicological evaluation of hydrochlorofluorocarbon 142b

Food and Chemical Toxicology, 1986
Groups of 110 rats of each sex were exposed by whole-body inhalation to 0, 1000, 10,000 or 20,000 ppm (v/v) of hydrochlorofluorocarbon 142b (CFC 142b or 1-chloro-1, 1-difluoroethane) for 6 hr/day, 5 days/wk for 104 wk (ten rats from each group were killed after 52 wk) in a combined chronic toxicity and oncogenicity study.
J A, Seckar, H J, Trochimowicz, G K, Hogan   +2 more
openaire   +2 more sources

Toxicological evaluation of cyclosporine eyedrops

Acta Ophthalmologica Scandinavica, 1999
The short-term toxicological effects of two cyclosporine A eyedrop formulations are compared.Formula A was based on Sandimmune (Novartis, Switzerland) infusion concentrate with a final ethanol concentration of 1% (w/w), and formula B on Sandimmune oral solution. Both formulations were diluted in sterile peanut oil (10 mg/ml).
S K, Knagenhjelm, K, Frøyland, A, Ringvold, E, Bjerkås, I, Kjønniksen   +4 more
openaire   +2 more sources

Toxicological evaluation of sodium perfluorohexanoate

Toxicology, 2009
Sodium perfluorohexanoate [NaPFHx, F(CF(2))(5)CO(2)Na, CAS#2923-26-4] was evaluated in acute, 90-day subchronic, one-generation reproduction, developmental and in vitro genetic toxicity studies. In the subchronic/one-generation reproduction study, four groups of young adult male and female Crl:CD(SD) rats were administered NaPFHx daily for ...
Scott E, Loveless, Brian, Slezak, Tessa, Serex, Joseph, Lewis, Pushkor, Mukerji, John C, O'Connor, E Maria, Donner, Steven R, Frame, Stephen H, Korzeniowski, Robert C, Buck   +9 more
openaire   +2 more sources

Toxicology and Evaluation of Microcystins

Therapeutic Drug Monitoring, 2000
This paper reviews the toxicity and tumor-promoting properties of microcystins. Methods for screening and/or identification of microcystins in environmental samples are discussed and compared. Specific emphasis is placed on newly developed extraction/detection methods, e.g., solid phase microextraction (SPME) technique, and capillary electrophoresis ...
P K, Lam, M, Yang, M H, Lam
openaire   +2 more sources

Toxicological Evaluation of u-hEGF

Toxicologic Pathology, 1995
The toxicological evaluation of urinary human epidermal growth factor (u-hEGF) included mutagenicity, single and repeated dose general toxicity, and teratogenicity studies in various animal species. The mutagenic potential of u-hEGF was tested in vitro (Ames test, chromosome aberration in human lymphocytes, unscheduled DNA synthesis in HeLa cells) and
R, Maraschin, R, Bussi, A, Conz, L, Orlando, R, Pirovano, A, Nyska   +5 more
openaire   +2 more sources

Toxicological evaluation of pure hydroxytyrosol

Food and Chemical Toxicology, 2013
Of all the phenolic constituents of olives and extra virgin olive oil, hydroxytyrosol is currently being actively exploited as a potential supplement or preservative to be employed in the nutraceutical, cosmeceutical, and food industry. In terms of safety profile, hydroxytyrosol has only been investigated as the predominant part of raw olive mill waste
Auñon Calles D, Canut L, VISIOLI, FRANCESCO   +2 more
openaire   +3 more sources