Results 91 to 100 of about 706,933 (359)

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Advances in the Use of Mass Spectral Libraries for Forensic Toxicology [PDF]

, 2017
Gas chromatography in combination with mass spectrometry (GC-MS) plays an important role in the field of analytical toxicology. The identification of unknown compounds is very frequently undertaken with GC-MS and utilizing mass spectral libraries ...
Aebi, Beat, Bernhard, Werner
core  

Isolation and characterisation of metallothionein from the clam Ruditapes decussatus [PDF]

, 2003
Metallothioneins (MT) were obtained after purification from metal-exposed clams (Ruditapes decussatus) using gel-permeation and ion-exchange chromatography.
Bebianno, Bebianno, Bebianno, Berger, Bernhard, Blum, Braun, Brouwer, Chan, Chubatsu, Coleman, Dabrio, Dallinger, Hammer, Kagi, Kagi, Kagi, Kagi, Kagi, Khoo, Kille, Langston, Lin, Lipman, Mackay, Mitra, Narula, Nordberg, Olafson, Pedersen, Raspor, Riek, Robbins, Roesijadi, Roesijadi, Schmidt, Unger, Vasak, Vasak, Wang, Winge, Zeng, Zeng   +42 more
core   +2 more sources

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source

Pesticide Mixture Poisoning: A Case Report

Arab Journal of Forensic Sciences & Forensic Medicine, 2018
Acute pesticide poisoning is a reported as major health problem worldwide and are reported mostly in cases of suicides and cases of unintentional poisoning are less in number. A significant number of cases are encountered in forensic science laboratories
Atul Bajaj, Cijo John, Sukhminder Kaur, Rohitashava M. Tripathi   +3 more
doaj   +1 more source

Binary and ternary toxicological interactions of clothianidin and eight commonly used pesticides on honey bees (Apis mellifera)

, 2021
Yanhua Wang, Yu Cheng Zhu, Wenhong Li, Jianxiu Yao, Gadi V. P. Reddy, Lu Lv   +5 more
openalex   +1 more source

Interfacial Bioengineering of Dynamic Networks Hybrid Hydrogel for Programmed Intervention in Oral Precancerous Epithelial States

Advanced Healthcare Materials, EarlyView.
This study develops a dual‐bioinspired hydrogel, MSA@PGel (macrophage membrane‐coated and salvianolic acid B/5‐aminolevulinic acid co‐loaded liposomes embedded in a polydopamine‐based gel), that integrates macrophage membrane‐mediated active targeting and mussel‐inspired wet adhesion for programmed intervention in oral precancerous lesions.
Xiaoxian Zhao, Ao Zheng, Zhengyan Zhao, Qilin Li, Tianhao Wan, Tanjun Deng, Ying Zhang, Lingyan Cao, Lan Wu   +8 more
wiley   +1 more source

Mechanistic evidence for dibutyl phthalate as an environmental trigger for inflammatory bowel disease

iScience
Summary: Dibutyl phthalate (DBP) is a ubiquitous pollutant, but its molecular link to inflammatory bowel disease (IBD) is undefined. We employed an integrative network toxicology framework, combining DBP target databases with IBD patient transcriptomics ...
Hang Yuan, Gang Chen, Xuejun Sun, Junhui Yu   +3 more
doaj   +1 more source

Commentary on: Attafi IM, Albeishy MY, Oraiby ME, Khardali IA, Shaikhain GA, Fageeh MM. Postmortem Distribution of Cathinone and Cathine in Human Biological Specimens in a Case of Death Associated wit

Arab Journal of Forensic Sciences & Forensic Medicine, 2019
The interpretation of post-mortem human tissue toxicology levels may be affected by the sampling site chosen. It is important to bear this in mind when looking at the psychoactive constituents of khat (Catha edulis Forsk) that have been consumed and have
John M. Corkery, Fabrizio Schifano, Amira Guirguis   +2 more
doaj   +1 more source