Results 21 to 30 of about 650,384 (309)

MMsPred: a bioactivity and toxicology predictive system [PDF]

, 2010
In the last decade, the development and use of new methods in combinatorial chemistry and high-throughput screening has dramatically increased the number of known biologically active compounds.
Joel Masciocchi, Luca Pani, Luca Pireddu, Matteo Floris, Patricia Rodriguez-Tome, Piergiorgio Palla, Ricardo Medda   +6 more
core   +2 more sources

Pioneer women in the development of toxicology in Brazil [PDF]

Brazilian Journal of Medical and Biological Research
Women have always played an important role in the development of toxicology all over the world. Specifically in Brazil, toxicology has had greater female representation than other countries, but women's participation at high hierarchical levels is low ...
L. Melo, T.S. Melo
doaj   +2 more sources

Simultaneous Measurement and Distribution Analysis of Urinary Nicotine, Cotinine, Trans-3′-Hydroxycotinine, Nornicotine, Anabasine, and Total Nicotine Equivalents in a Large Korean Population

Molecules, 2023
Measurement of multiple nicotine metabolites and total nicotine equivalents (TNE) might be a more reliable strategy for tobacco exposure verification than measuring single urinary cotinine alone.
Hyun-Seung Lee, Mi-Ryung Chun, Soo-Youn Lee   +2 more
doaj   +1 more source

Nephroprotective Effect of L-Carvone on a Mouse Model of LPS-Induced Sepsis-Associated Renal Injury via Regulation of TLR4/NF-κB/AP-1/IRF-3 and Nrf2/iNOS Molecular Signaling Cascades

Journal of Taibah University Medical Sciences
الملخص: أهداف البحث: يُعد الإنتان من الحالات السريرية الخطيرة الناتجة عن استجابة مناعية غير منضبطة، تؤدي إلى التهاب جهازي واسع النطاق وإصابة متعددة للأعضاء، وتُعد الكلى من أكثر الأعضاء تأثرًا.
Saja M. Shareef, PhD (Pharmacology and Toxicology), Sarmed H. Kathem, PhD (Pharmacology and Toxicology), Hayder Ridha-Salman, PhD (Pharmacology)   +2 more
doaj   +1 more source

Proteomics for systems toxicology

Computational and Structural Biotechnology Journal, 2014
Current toxicology studies frequently lack measurements at molecular resolution to enable a more mechanism-based and predictive toxicological assessment.
Bjoern Titz, Ashraf Elamin, Florian Martin, Thomas Schneider, Sophie Dijon, Nikolai V. Ivanov, Julia Hoeng, Manuel C. Peitsch   +7 more
doaj   +1 more source

Network toxicology and its application in studying exogenous chemical toxicity

环境与职业医学
With the continuous development of society, a large number of new chemicals are continuously emerging, which presents a challenge to current risk assessment and safety management of chemicals.
Yanli LIN, Zehua TAO, Zhao XIAO, Chenxu HU, Bobo YANG, Ya WANG, Rongzhu LU   +6 more
doaj   +1 more source

A Holistic Assessment of Polyethylene Fiber Ingestion in Larval and Juvenile Japanese Medaka Fish

Frontiers in Physiology, 2021
Microplastic pollution is of public concern for global environmental health, aquaculture, and fisheries. Toxicity studies have shown that microplastic ingestion may cause intestinal damage, microbiota dysbiosis, and disturb the lipid and energy ...
Elizabeth DiBona, Lee J. Pinnell, Annika Heising-Huang, Simon Geist, Jeffrey W. Turner, Jeffrey W. Turner, Frauke Seemann, Frauke Seemann   +7 more
doaj   +1 more source

Semiconductor Electronic Label-Free Assay for Predictive Toxicology. [PDF]

, 2016
While animal experimentations have spearheaded numerous breakthroughs in biomedicine, they also have spawned many logistical concerns in providing toxicity screening for copious new materials. Their prioritization is premised on performing cellular-level
Chui, Chi On, Ji, Zhaoxia, Mao, Yufei, Meng, Huan, Shin, Kyeong-Sik, Wang, Xiang   +5 more
core   +2 more sources

A new occupational and environmental hazard – nanoplastic

Medycyna Pracy, 2020
Problems arising from the accumulation of plastic waste in the environment have become global. Appeals to stop the usage of disposable drinking straws or plastic cutlery did not come out without reason – 320 million tons of plastic products are produced ...
Michał Rakowski, Agnieszka Grzelak
doaj   +1 more source

Botulinum Neurotoxins (BoNTs) and Their Biological, Pharmacological, and Toxicological Issues: A Scoping Review

Applied Sciences, 2021
Botulinum toxins or neurotoxins (BoNTs) are the most potent neurotoxins known, and are currently extensively studied, not only for their potential lethality, but also for their possible therapeutic and cosmetic uses.
Massimo Corsalini, Francesco Inchingolo, Gianna Dipalma, Angelika Elzbieta Wegierska, Ioannis Alexandros Charitos, Maria Assunta Potenza, Antonio Scarano, Felice Lorusso, Alessio Danilo Inchingolo, Monica Montagnani, Luigi Santacroce   +10 more
doaj   +1 more source