Results 31 to 40 of about 388,698 (305)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

In Vitro, Oral Acute, and Repeated 28-Day Oral Dose Toxicity of a Mixed-Valence Polyoxovanadate Cluster

Pharmaceuticals, 2023
Polyoxovanadates (POV) are a subgroup of polyoxometalates (POM), which are nanosized clusters with reported biological activities. This manuscript describes the first toxicity evaluation of a mixed-valence polyoxovanadate, pentadecavanadate, (Me4N)6 ...
Mariana de M. Barbosa, Lidiane M. A. de Lima, Widarlane A. da S. Alves, Eucilene K. B. de Lima, Luzia A. da Silva, Thiago D. da Silva, Kahoana Postal, Mohammad Ramadan, Kateryna Kostenkova, Dayane A. Gomes, Giovana G. Nunes, Michelly C. Pereira, Wagner E. da Silva, Mônica F. Belian, Debbie C. Crans, Eduardo C. Lira   +15 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Toxicology Handbook [PDF]

, 2015
Toxicology Handbook is a practical evidence-based guide on the care of the poisoned patient. This concise text is informed by the latest clinical research and takes a rigorous and structured risk assessment-based approach to decision making in the ...
Little, Mark, Pascu, Ovidiu, Hoggett, Kerry, Murray, Lindsay   +3 more
core   +1 more source

A Comparative Analysis of Toxicology and Non-Toxicology Care in Intoxicated Patients with Acute Kidney Injury

Medicina
Background and Objectives: Intoxicated patients with acute kidney injury (AKI) experience high morbidity and mortality. While prior studies suggest that toxicology care settings improve outcomes, the impact of care settings on patients with AKI remains ...
Chi-Syuan Pan, Chun-Hung Chen, Wei-Kung Chen, Han-Wei Mu, Kai-Wei Yang, Jiun-Hao Yu   +5 more
doaj   +1 more source

Parthenin—A Sesquiterpene Lactone with Multifaceted Biological Activities: Insights and Prospects

Molecules, 2021
Parthenin, a sesquiterpene lactone of pseudoguaianolide type, is the representative secondary metabolite of the tropical weed Parthenium hysterophorus (Asteraceae).
Amarpreet Kaur, Shalinder Kaur, Rupali Jandrotia, Harminder Pal Singh, Daizy Rani Batish, Ravinder Kumar Kohli, Virendra Singh Rana, Najam A. Shakil   +7 more
doaj   +1 more source

Toxicology research for precautionary decision-making and the role of Human & Experimental Toxicology [PDF]

, 2017
A key aim of toxicology is the prevention of adverse effects due to toxic hazards. Therefore, the dissemination of toxicology research findings must confront two important challenges: one being the lack of information on the vast majority of potentially ...
Grandjean, Philippe
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Assessing the scientific research productivity of a leading toxicology journal: A case study of from 2003 to 2012

SAGE Open Medicine, 2014
Background: Bibliometric studies are increasingly being used for research assessments. Bibliometric indicators involve the application of statistical methods to scientific publications to obtain the bibliographics for each journal.
Sa’ed H Zyoud, Samah W Al-Jabi, Waleed M Sweileh, Rahmat Awang   +3 more
doaj   +1 more source

The Concentration of Selected Heavy Metals in Muscles, Liver and Kidneys of Pigs Fed Standard Diets and Diets Containing 60% of New Rye Varieties

Animals, 2021
The carry-over of heavy metals from feed to muscles is generally low if animals are fed with a standard diet containing amounts below the maximum permissible levels.
Agnieszka Chałabis-Mazurek, Jose Luis Valverde Piedra, Siemowit Muszyński, Ewa Tomaszewska, Sylwia Szymańczyk, Sylwester Kowalik, Marcin B. Arciszewski, Anna Zacharko-Siembida, Tomasz Schwarz   +8 more
doaj   +1 more source