Results 321 to 330 of about 839,197 (349)

The evolving role of investigative toxicology in the pharmaceutical industry

open access: yesNature Reviews Drug Discovery, 2023
For decades, preclinical toxicology was essentially a descriptive discipline in which treatment-related effects were carefully reported and used as a basis to calculate safety margins for drug candidates.
Francois Pognan, , Richard J Weaver
exaly   +2 more sources

Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

open access: yesMolecules, 2020
Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres,
Aleksandra Zielińska   +2 more
exaly   +2 more sources

In silico toxicology: From structure–activity relationships towards deep learning and adverse outcome pathways

open access: yesWiley Interdisciplinary Reviews: Computational Molecular Science, 2020
In silico toxicology is an emerging field. It gains increasing importance as research is aiming to decrease the use of animal experiments as suggested in the 3R principles by Russell and Burch.
Jennifer Hemmerich, Gerhard F Ecker
exaly   +2 more sources

Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

open access: yesNature Communications, 2019
Metabolomics is a widely used technology in academic research, yet its application to regulatory science has been limited. The most commonly cited barrier to its translation is lack of performance and reporting standards.
Mark R Viant   +2 more
exaly   +2 more sources
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Mycotoxins: Occurrence, toxicology, and exposure assessment

Food and Chemical Toxicology, 2013
German Cano-Sancho, Vicente Sanchis
exaly   +2 more sources

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