Results 81 to 90 of about 791,172 (411)

The digital evolution in toxicology: pioneering computational education for emerging challenges

BMC Medical Education
The educational landscape of toxicology is increasingly integrating computational methodologies due to ethical concerns about animal testing and advancements in biotechnological and data analysis tools.
Jin Wang, Jianxiang Li
doaj   +1 more source

Occupational medicine and toxicology

Journal of Occupational Medicine and Toxicology, 2006
This editorial is to announce the Journal of Occupational Medicine and Toxicology, a new Open Access, peer-reviewed, online journal published by BioMed Central.
Fischer Axel, Groneberg David A
doaj   +1 more source

Evaluation of histological findings with severity grade, to analyze toxicology in-vivo studies [PDF]

arXiv, 2022
In-vivo toxicological studies are characterized by multiple primary endpoints with quite different scales. Whereas guidelines and publications provide various statistical tests for normally distributed endpoints (such as organ weights) and proportions (such as tumor rates), few approaches are available for graded histopathological findings, such as 0, +
arxiv  

Basic & Clinical Pharmacology & Toxicology Policy for Experimental and Clinical studies.

Basic & Clinical Pharmacology & Toxicology, 2018
Inconsistencies in the reproducibility of research findings are of pertinent concern throughout the scientific community. Initially addressed in preclinical biomedicine studies [1, 2], the discussion has expanded to fields outside the natural sciences ...
P. Tveden-Nyborg, T. Bergmann, J. Lykkesfeldt   +2 more
semanticscholar   +1 more source

Is the cause toxicological?

The Foundation Years, 2003
The diagnosis of poisoning is often obvious (e.g. in a patient presenting with drug overdose), but can sometimes be more challenging. This article describes some clinical presentations where poisoning should be considered in the differential diagnosis.
openaire   +3 more sources

A Bioengineered Model of the Human Cornea for Preclinical Assessment of Human Ocular Exposure to Environmental Toxicants

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This paper presents a microphysiological system containing an array of individually addressable living corneal tissues constructed using primary human cells. The bioengineered eye model can simulate acute exposure of the human cornea to different types of environmental toxicants and provides a novel platform for visualization and quantitative ...
Se‐jeong Kim, Ning Guo, Zong Yao Tan, Xing Gao, Pouria Fattahi, Haijiao Liu, Jeehan Chang, Mousa Younesi, Selice Jung, Yewhan Chung, Minkyung Song, Michelle Jung, Dan Dongeun Huh   +12 more
wiley   +1 more source

Hepatotoxic metabolites in Polygoni Multiflori Radix— Comparative toxicology in mice

Frontiers in Pharmacology, 2022
Polygoni Multiflori Radix (PM) and Rhei radix et rhizoma (rhubarb) contain similar hepatocyte-toxic anthraquinones such as emodin (major free anthraquinone in PM), physcion and their glycosides.
Shixiao Wang, Shixiao Wang, Xiang Kong, Xiang Kong, Ning Chen, Ning Chen, Pengwei Hu, Pengwei Hu, Hamza Boucetta, Hamza Boucetta, Zhaoliang Hu, Zhaoliang Hu, Xin Xu, Xin Xu, Pei Zhang, Pei Zhang, Xiang Zhan, Xiang Zhan, Ming Chang, Ming Chang, Rui Cheng, Rui Cheng, Wei Wu, Wei Wu, Min Song, Min Song, Yuting Lu, Yuting Lu, Taijun Hang, Taijun Hang   +29 more
doaj   +1 more source

Claiming trend in toxicological and pharmacological dose-response studies: an overview on statistical methods and related R-Software [PDF]

arXiv, 2020
There are very different statistical methods for demonstrating a trend in pharmacological experiments. Here, the focus is on sparse models with only one parameter to be estimated and interpreted: the increase in the regression model and the difference to control in the contrast model.
arxiv  

Classification of chemical compounds based on the correlation between \textit{in vitro} gene expression profiles [PDF]

Bulletin of Informatics and Cybernetics, 53(4) (2021), 1-14, 2021
Toxicity evaluation of chemical compounds has traditionally relied on animal experiments;however, the demand for non-animal-based prediction methods for toxicology of compounds is increasing worldwide. Our aim was to provide a classification method for compounds based on \textit{in vitro} gene expression profiles.
arxiv  

Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety

International Journal of Molecular Sciences, 2018
Pyrrolizidine alkaloids (PA) are widely distributed in plants throughout the world, frequently in species relevant for human consumption. Apart from the toxicity that these molecules can cause in humans and livestock, PA are also known for their wide ...
Rute Moreira, David M. Pereira, P. Valentão, P. Andrade   +3 more
semanticscholar   +1 more source