Results 91 to 100 of about 875,495 (362)
To be or not to be: regulation of restriction–modification systems and other toxin–antitoxin systems
Nucleic Acids Research, 2013 One of the simplest classes of genes involved in programmed death is that containing the toxin–antitoxin (TA) systems of prokaryotes. These systems are composed of an intracellular toxin and an antitoxin that neutralizes its effect.
Iwona Mruk, I. Kobayashi
semanticscholar +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
The Titration of Diphtheria Toxin and Antitoxin by Ramon's Flocculation Method [PDF]
, 1924 Stanhope Bayne‐Jones
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JAMA: The Journal of the American Medical Association, 1899 The human body, in its normal or its pathologic state is the theater of the toxic elaborations carried on either by the organism itself, or by the microbes which are normal inhabitants, or by those which are guests of the alimentary canal. In the first rank come the mineral substances taken with our food, even the most inoffensive, particularly on ...
openaire +2 more sources
Toxin B is essential for virulence of Clostridium difficile
Nature, 2009 Clostridium difficile is the leading cause of infectious diarrhoea in hospitals worldwide, because of its virulence, spore-forming ability and persistence. C.
D. Lyras +11 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
The Treatment of Inoperable Sarcoma by Bacterial Toxins (the Mixed Toxins of the Streptococcus erysipelas and the Bacillus prodigiosus). [PDF]
, 1910 WILLIAM B. COLEY
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Toxin Inactivation in Toxin/Antitoxin Systems
, 2019 Toxin/antitoxin (TA) systems are used primarily to inhibit phage, reduce metabolic activity during stress, and maintain genetic elements. Given the extreme toxicity of some of the toxins of these TA systems, we were curious how the cell silences toxins, if the antitoxin is inactivated or when toxins are obtained without antitoxins via horizontal gene ...
Laura Fernandez-Garcia +3 more
openaire +3 more sources