Results 101 to 110 of about 880,943 (314)

Probiotic Microorganisms Inhibit Epithelial Cell Internalization of Botulinum Neurotoxin Serotype A

Toxins, 2016
Botulinum neurotoxins (BoNTs) are some of the most poisonous natural toxins known to man and are threats to public health and safety. Previous work from our laboratory showed that both BoNT serotype A complex and holotoxin can bind and transit through ...
Tina I. Lam, Christina C. Tam, Larry H. Stanker, Luisa W. Cheng   +3 more
doaj   +1 more source

Effects of adaptation, chance, and history on the evolution of the toxic dinoflagellate Alexandrium minutum under selection of increased temperature and acidification [PDF]

, 2018
The roles of adaptation, chance, and history on evolution of the toxic dinoflagellate Alexandrium minutum Halim, under selective conditions simulating global change, have been addressed.
Anderson, Anderson, Beardall, Belin, Bell, Blount, Boyer, Bull, Caldeira, Colegrave, Collins, Collins, Cooper, Costas, Costas, Costas, Crow, Cuevas, Elbrachter, Fahnenstiel, Flores-Moya, Flynn, Franco, Godhe, Gould, Gould, Gould, Guisande, Hallegraeff, Hallegraeff, Hallegraeff, Hansen, Hansen, Hoagland, Hwang, IPCC, Intergovermental Panel on Climate Change, Kimura, Lenski, Lilly, Martins, Mendoza, Nehring, Ogata, Parkhill, Persich, Persson, Pitcher, Pérez-Zaballos, Raven, Reboud, Rost, Rouco, Spiess, Travisano, Usup, Vila, Wagenaar, Whitlock, Wright, Yoshida, Zar, Zeebe   +61 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The clinical features, diagnosis, and treatment of cognitive impairments in Parkinson's disease

Неврология, нейропсихиатрия, психосоматика, 2017
The review presents the data of recent studies dealing with cognitive impairments (CI) in patients with Parkinson's disease (PD) and gives their characteristics and epidemiology, the specific features of the pathogenesis and clinical manifestations, as ...
G. N. Akhmadeeva, R. V. Magzhanov, G. N. Tayupova, A. R. Baitimerov   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Preparation and neutralization efficacy of IgY antibodies raised against Deinagkistrodon acutus venom

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
Background The five-paced pit viper (Deinagkistrodon acutus), endemic to China and northern Vietnam, is responsible for most snakebites in the Chinese territory.
Jinhua Liu, Qiyi He, Wenwen Wang, Bin Zhou, Bo Li, Yingfeng Zhang, Cong Luo, Diancheng Chen, Jia Tang, Xiaodong Yu   +9 more
doaj   +1 more source

Ca2+-Stimulated Catecholamine Release from alpha-Toxin Permeabilized PC12 Cells [PDF]

, 1987
Two possible cellular pathways of catecholamines from the chromaffin vesicles of PC 12 cells to the surrounding medium are explored in this study. The direct one circumventing the cytoplasm can be activated in a-toxin-permeabilized cells with micromolar ...
Ahnert-Hilger, G., Bräutigam, M., Gratzl, Manfred   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The effects of storage conditions on viability of Clostridium difficile vegetative cells and spores and toxin activity in human faeces [PDF]

, 2003
AIMS: Clostridium difficile is a common nosocomial pathogen and as such diagnostic and research methods may necessitate storage of faecal specimens for long periods, followed by subsequent re-examination.
Freeman, J., Wilcox, M.H.
core   +1 more source