Results 121 to 130 of about 642,336 (319)

Expression of cholera toxin B subunit in Saccharomyces cerevisiae [PDF]

Cholera toxin, secreted by Vibrio cholerae, consists of A and B subunits. Cholera toxin B subunit (CTB) is used in many scientific research. It has already been expressed in several bacterial and plant systems.
ارزنلو, محسن, آهنگرزاده رضایی, محمد, زواران حسینی, احمد, توچیکوبو, کونیو, شاهرخی, نادر, یاسودا, یوکو, رضایی, عباس   +6 more
core  

Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins [PDF]

, 2007
Retrograde transport allows proteins and lipids to leave the endocytic pathway to reach other intracellular compartments, such as trans-Golgi network (TGN)/Golgi membranes, the endoplasmic reticulum and, in some instances, the cytosol. Here, we have used
Falguières, Thomas, Roberts, L., Smith, Daniel C., Lord, J., Fradagrada, Alexandre, Amessou, Mohamed, Amessou, M., Johannes, Ludger, Fradagrada, A., Falguieres, T., Lord, Mike, Roberts, L. M. (Lynne M.), Lamaze, Christophe, Lamaze, C., Johannes, L., Smith, D.   +15 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Identification of a key residue for Oligomerisation and pore-formation of Clostridium perfringens NetB

, 2014
Necrotic enteritis toxin B (NetB) is a β-pore-forming toxin produced by Clostridium perfringens and has been identified as a key virulence factor in the pathogenesis of avian necrotic enteritis, a disease causing significant economic damage to the ...
Richard W. Titball, Sérgio P. Fern, Claire Naylor, Bokori-Brown, M., Moss, David S., Titball, Richard W., David S. Moss, Christos Savva, Naylor, Claire E., Es Da Costa, Fernandes da Costa, Sérgio P., Ajit K. Basak, David Moss, Sérgio P. Fernandes da Costa, Titball, R., Monika Bokori-Brown, Claire E. Naylor, Ajit Basak, Richard Titball, Basak, Ajit K., Bokori-Brown, Monika, da Costa, S., Sérgio Fernandes da Costa, Christos G. Savva, Savva, Christos G.   +24 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Prevalence and genetic characterization of shiga toxin-producing Escherichia coli isolates from slaughtered animals in Bangladesh

, 2008
To determine the prevalence of Shiga toxin (Stx)-producing Escherichia coli (STEC) in slaughter animals in Dhaka, Bangladesh, we collected rectal contents immediately after animals were slaughtered.
Beumer, R.R., Boer, E., de, de Boer, E., Islam, M.A., Talukder, K.A., Zwietering, M.H., Mondol, A.S., Heuvelink, A.E.   +7 more
core   +1 more source

Mendelian randomization and multiomics comprehensively reveal the causal relationship and potential mechanism between atrial fibrillation and gastric cancer

Frontiers in Genetics
ObjectiveGastric cancer is a harmful disease, the comorbidity mechanism and causality relationship between this disease and other diseases are worth studying.MethodsUsing a two-sample Mendelian Randomization method, this study revealed the potential ...
Zhao Sicheng, Zhao Sicheng, Zhang Jingcheng, Zhang Jingcheng, Zhang Shuo, Zhang Shuo, Lou Jiaheng, Lou Jiaheng, Cai Yan, Cai Yan, Bai Xing, Bai Xing, Jiang Tao, Jiang Tao, Jiang Tao, Zhang Guangji, Zhang Guangji, Zhang Guangji   +17 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Quantification of the emetic toxin cereulide in food products by liquid chromatography-mass spectrometry using synthetic cereulide as a standard

, 2010
Bacillus cereus produces the emetic toxin cereulide, a cyclic dodecadepsipeptide that can act as a K+ ionophore, dissipating the transmembrane potential in mitochondria of eukaryotic cells.
de Veld, P., Monika Ehling-Schulz, Paul H. in ′t Veld, Abee, T., in 't Veld, Paul H, Elisabeth G. Biesta-Peters, Ehling-Schulz, M., Biesta-Peters, E.G., Abee, Tjakko, Martine W. Reij, Richard H. Blaauw, Reij, M.W., Veld, P., de, Blaauw, R.H., Reij, Martine W, Rajkovic, Andreja, Blaauw, Richard H, Tjakko Abee, Rajkovic, A., Ehling-Schulz, Monika, Biesta-Peters, Elisabeth G, Andreja Rajkovic   +21 more
core   +1 more source

Chronic low-grade inflammation associated with higher risk and earlier onset of cardiometabolic multimorbidity in middle-aged and older adults: a population-based cohort study

Scientific Reports
Evidence regarding the role of chronic low-grade inflammation in the progression of cardiometabolic diseases (CMDs) and cardiometabolic multimorbidity (CMM) is currently limited. This prospective cohort study, utilising data from the UK Biobank, included
Wenke Cheng, Zhongyan Du, Bo Lu
doaj   +1 more source