Neutralizing Monoclonal Antibody, mAb 10D8, Is an Effective Detoxicant against Abrin-a Both In Vitro and In Vivo [PDF]
Toxins, 2022 Abrin is a types II ribosome-inactivating protein (RIP) isolated from Abrus precatorious seeds, which comprises a catalytically active A chain and a lectin-like B chain linked by a disulfide bond.
Jianwei Xie, Hua Xu, Bo Ma
exaly +5 more sources
Detection of Abrin Holotoxin Using Novel Monoclonal Antibodies
Toxins, 2017 Abrin, a member of the ribosome-inactivating protein family, is produced by the Abrus precatorius plant. Having the potential to pose a severe threat to both human and animal health, abrin is classified as a Select Agent by the U.S.
Reuven Rasooly +2 more
exaly +4 more sources
Rapid Differential Detection of Abrin Isoforms by an Acetonitrile- and Ultrasound-Assisted On-Bead Trypsin Digestion Coupled with LC-MS/MS Analysis [PDF]
Toxins, 2021 The high toxic abrin from the plant Abrus precatorius is a type II ribosome-inactivating protein toxin with a human lethal dose of 0.1–1.0 µg/kg body weight.
Long-Hui Liang +6 more
doaj +3 more sources
Differentiation, Quantification and Identification of Abrin and Abrus precatorius Agglutinin [PDF]
Toxins, 2021 Abrin, the toxic lectin from the rosary pea plant Abrus precatorius, has gained considerable interest in the recent past due to its potential malevolent use.
Sylvia Worbs +9 more
doaj +4 more sources
A Novel Humanized Anti-Abrin A Chain Antibody Inhibits Abrin Toxicity In Vitro and In Vivo [PDF]
Frontiers in Immunology, 2022 Abrin, a type-II ribosome inactivating protein from the seed of Abrus precatorius, is classified as a Category B bioterrorism warfare agent. Due to its high toxicity, ingestion by animals or humans will lead to death from multiple organ failure ...
Jingyi Peng +15 more
doaj +5 more sources
N-Glycosylation Profile of Abrin Certified EU Reference Material [PDF]
ToxinsAbrin is a highly toxic plant protein encompassing four isoforms, abrin-a, -b, -c and -d. An abrin reference material was isolated from Abrus precatorius and certified (EURM-113) by the EuroBioTox consortium.
Roland Josuran +6 more
doaj +4 more sources
Characterization of Lung Injury following Abrin Pulmonary Intoxication in Mice: Comparison to Ricin Poisoning [PDF]
Toxins, 2022 Abrin is a highly toxic protein obtained from the seeds of the rosary pea plant Abrus precatorius, and it is closely related to ricin in terms of its structure and chemical properties.
Anita Sapoznikov +6 more
doaj +3 more sources
Abrin Toxin Paradoxically Increases Protein Synthesis in Stimulated CD4+ T-Cells While Decreasing Protein Synthesis in Kidney Cells [PDF]
Current Issues in Molecular BiologyAbrin, a toxin of the rosary pea plant (Abras precatorius), has been implicated as causing an autoimmune demyelinating disease in humans, but the exact mechanisms responsible for the induction of these demyelinating conditions are still unknown.
Bradley Hernlem, Reuven Rasooly
doaj +3 more sources
Differential Thermal Inactivation Enables Simultaneous Quantitation of Ricin and Abrin [PDF]
ToxinsRicin and abrin are highly lethal Type II ribosome-inactivating proteins. They depurinate the same site of the 28S rRNA to inhibit protein synthesis. Consequently, standard molecular-level activity assays used to detect the toxic activity of ricin or ...
Woo-Hyeon Jeong
doaj +2 more sources
Development and Evaluation of an Immuno-MALDI-TOF Mass Spectrometry Approach for Quantification of the Abrin Toxin in Complex Food Matrices [PDF]
Toxins, 2021 The toxin abrin found in the seeds of Abrus precatorius has attracted much attention regarding criminal and terroristic misuse over the past decade. Progress in analytical methods for a rapid and unambiguous identification of low abrin concentrations in ...
Sandrine Livet +7 more
doaj +2 more sources