N-Glycosylation Profile of Abrin Certified EU Reference Material [PDF]
ToxinsAbrin is a highly toxic plant protein encompassing four isoforms, abrin-a, -b, -c and -d. An abrin reference material was isolated from Abrus precatorius and certified (EURM-113) by the EuroBioTox consortium.
Roland Josuran +6 more
doaj +4 more sources
Characterization of Lung Injury following Abrin Pulmonary Intoxication in Mice: Comparison to Ricin Poisoning [PDF]
Toxins, 2022 Abrin is a highly toxic protein obtained from the seeds of the rosary pea plant Abrus precatorius, and it is closely related to ricin in terms of its structure and chemical properties.
Anita Sapoznikov +6 more
doaj +4 more sources
Neutralizing Monoclonal Antibody, mAb 10D8, Is an Effective Detoxicant against Abrin-a Both In Vitro and In Vivo [PDF]
Toxins, 2022 Abrin is a types II ribosome-inactivating protein (RIP) isolated from Abrus precatorious seeds, which comprises a catalytically active A chain and a lectin-like B chain linked by a disulfide bond.
Zhi Li +8 more
doaj +4 more sources
A Novel Humanized Anti-Abrin A Chain Antibody Inhibits Abrin Toxicity In Vitro and In Vivo [PDF]
Frontiers in Immunology, 2022 Abrin, a type-II ribosome inactivating protein from the seed of Abrus precatorius, is classified as a Category B bioterrorism warfare agent. Due to its high toxicity, ingestion by animals or humans will lead to death from multiple organ failure ...
Jingyi Peng +15 more
doaj +6 more sources
Differentiation, Quantification and Identification of Abrin and Abrus precatorius Agglutinin [PDF]
Toxins, 2021 Abrin, the toxic lectin from the rosary pea plant Abrus precatorius, has gained considerable interest in the recent past due to its potential malevolent use.
Sylvia Worbs +9 more
doaj +5 more sources
Differential Thermal Inactivation Enables Simultaneous Quantitation of Ricin and Abrin [PDF]
ToxinsRicin and abrin are highly lethal Type II ribosome-inactivating proteins. They depurinate the same site of the 28S rRNA to inhibit protein synthesis. Consequently, standard molecular-level activity assays used to detect the toxic activity of ricin or ...
Woo-Hyeon Jeong
doaj +3 more sources
Detection of Abrin Holotoxin Using Novel Monoclonal Antibodies
Toxins, 2017 Abrin, a member of the ribosome-inactivating protein family, is produced by the Abrus precatorius plant. Having the potential to pose a severe threat to both human and animal health, abrin is classified as a Select Agent by the U.S.
Xiaohua He +2 more
exaly +4 more sources
Sensitive Detection and Differentiation of Biologically Active Ricin and Abrin in Complex Matrices via Specific Neutralizing Antibody-Based Cytotoxicity Assay [PDF]
ToxinsRicin and abrin are highly potent plant-derived toxins, categorized as type II ribosome-inactivating proteins. High toxicity, accessibility, and the lack of effective countermeasures make them potential agents in bioterrorism and biowarfare, posing ...
Zhi Li +6 more
doaj +3 more sources
Establishment and Comparison of Detection Methods for Ricin and Abrin Based on Their Depurination Activities [PDF]
ToxinsRicin (RT) and abrin (AT) are plant toxins extracted from Ricinus communis and Abrus precatorius, respectively, and both have N-glycosidase activity. The detection of these toxins is vital because of their accessibility and bioterrorism potential.
Lina Dong +9 more
doaj +3 more sources
Ricin and Abrin in Biosecurity: Detection Technologies and Strategic Responses [PDF]
ToxinsPlant-derived toxins such as ricin and abrin represent some of the most potent biological agents known, posing significant threats to public health and security due to their high toxicity, relative ease of extraction, and widespread availability.
Wojciech Zajaczkowski +8 more
doaj +3 more sources