Abrin Toxin Paradoxically Increases Protein Synthesis in Stimulated CD4+ T-Cells While Decreasing Protein Synthesis in Kidney Cells [PDF]
Current Issues in Molecular BiologyAbrin, a toxin of the rosary pea plant (Abras precatorius), has been implicated as causing an autoimmune demyelinating disease in humans, but the exact mechanisms responsible for the induction of these demyelinating conditions are still unknown.
Bradley Hernlem, Reuven Rasooly
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Establishment and Comparison of Detection Methods for Ricin and Abrin Based on Their Depurination Activities [PDF]
ToxinsRicin (RT) and abrin (AT) are plant toxins extracted from Ricinus communis and Abrus precatorius, respectively, and both have N-glycosidase activity. The detection of these toxins is vital because of their accessibility and bioterrorism potential.
Lina Dong +9 more
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Sensitive Detection and Differentiation of Biologically Active Ricin and Abrin in Complex Matrices via Specific Neutralizing Antibody-Based Cytotoxicity Assay [PDF]
ToxinsRicin and abrin are highly potent plant-derived toxins, categorized as type II ribosome-inactivating proteins. High toxicity, accessibility, and the lack of effective countermeasures make them potential agents in bioterrorism and biowarfare, posing ...
Zhi Li +6 more
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Ricin and Abrin in Biosecurity: Detection Technologies and Strategic Responses [PDF]
ToxinsPlant-derived toxins such as ricin and abrin represent some of the most potent biological agents known, posing significant threats to public health and security due to their high toxicity, relative ease of extraction, and widespread availability.
Wojciech Zajaczkowski +8 more
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A New Method for Abrin Detection Based on the Interaction between Target Molecules and Fluorescently Labeled Aptamers on Magnetic Microspheres. [PDF]
Materials (Basel), 2022 A quantitative structure–activity relationship (QSAR) model for the structure and affinity of abrin aptamers was established. A higher affinity abrin aptamer based on the established QSAR model was screened by site-directed mutagenesis.
Liu Z +9 more
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A Glycoprotein-Based Surface-Enhanced Raman Spectroscopy–Lateral Flow Assay Method for Abrin and Ricin Detection [PDF]
ToxinsAbrin and ricin, both type II ribosome-inactivating proteins, are toxins of significant concern and are under international restriction by the Chemical Weapons Convention and the Biological and Toxin Weapons Convention.
Lan Xiao +8 more
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Ricin and Abrin as Possible Agents of Bioterror
Вестник войск РХБ защиты, 2022 Plant toxins – ricin and abrin, obtained in a purified form from the beans of the castor bean and Abrus precatorius respectively, are considered by Western experts as potential damaging agents of a biological nature.
D. V. Pechenkin +5 more
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A Self-Driven Microfluidic Chip for Ricin and Abrin Detection [PDF]
Sensors, 2022 Ricin and abrin are phytotoxins that can be easily used as biowarfare and bioterrorism agents. Therefore, developing a rapid detection method for both toxins is of great significance in the field of biosecurity.
Xuexin Bai +13 more
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Abrin immunotoxin: targeted cytotoxicity and intracellular trafficking pathway.
PLoS ONE, 2013 BackgroundImmunotherapy is fast emerging as one of the leading modes of treatment of cancer, in combination with chemotherapy and radiation. Use of immunotoxins, proteins bearing a cell-surface receptor-specific antibody conjugated to a toxin, enhances ...
Sudarshan Gadadhar, Anjali A Karande
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Simultaneous Detection of Ricin and Abrin DNA by Real-Time PCR (qPCR)
Toxins, 2012 Ricin and abrin are two of the most potent plant toxins known and may be easily obtained in high yield from the seeds using rather simple technology. As a result, both toxins are potent and available toxins for criminal or terrorist acts. However, as the
Roman Wölfel +3 more
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