Whole-Cell Multiparameter Assay for Ricin and Abrin Activity-Based Digital Holographic Microscopy [PDF]
Toxins, 2019 Ricin and abrin are ribosome-inactivating proteins leading to inhibition of protein synthesis and cell death. These toxins are considered some of the most potent and lethal toxins against which there is no available antidote.
Efi Makdasi +5 more
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Endoplasmic reticulum stress-mediated activation of p38 MAPK, Caspase-2 and Caspase-8 leads to abrin-induced apoptosis. [PDF]
PLoS ONE, 2014 Abrin from Abrus precatorius plant is a potent protein synthesis inhibitor and induces apoptosis in cells. However, the relationship between inhibition of protein synthesis and apoptosis is not well understood.
Ritu Mishra, Anjali A Karande
doaj +3 more sources
Biomedical Research Journal, 2017 Abrin is a highly lethal ribosome-inactivating protein of high relevance in bio-warfare. Neutralizing antibodies to abrin reported so far afford protection in a very small window with no rescue observed post-abrin exposure.
Meenakshi Sundaram Kumar +3 more
doaj +2 more sources
Abrin Toxicity and Bioavailability after Temperature and pH Treatment
Toxins, 2017 Abrin, one of most potent toxins known to man, is derived from the rosary pea (jequirity pea), Abrus precatorius and is a potential bioterror weapon.
Xiaohua He, Luisa W Cheng
exaly +3 more sources
Detection of Abrin by Electrochemiluminescence Biosensor Based on Screen Printed Electrode [PDF]
Sensors, 2018 For the convenience of fast measurement in the outdoor environment, a portable electrochemiluminescence biosensor with the screen-printed electrode as the reaction center was developed, which possesses the characteristics of high sensitivity, small scale,
Shuai Liu +6 more
doaj +2 more sources
A New Method for Abrin Detection Based on the Interaction between Target Molecules and Fluorescently Labeled Aptamers on Magnetic Microspheres. [PDF]
Materials (Basel), 2022 Liu Z +9 more
europepmc +3 more sources
A monoclonal antibody to an abrin chimera recognizing a unique epitope on abrin A chain confers protection from abrin-induced lethality [PDF]
Human Vaccines & Immunotherapeutics, 2015 Abrin, obtained from the seeds of Abrus precatorius plant, is a potent toxin belonging to the family of type II ribosome-inactivating proteins. Recently, a recombinant vaccine consisting of the A subunits of abrin and its homolog Abrus precatorius agglutinin (APA) was demonstrated to protect mice from abrin lethality.
Meenakshi Sundaram Kumar +1 more
openalex +4 more sources
THE HISTOLOGICAL CHANGES PRODUCED BY RICIN AND ABRIN INTOXICATIONS [PDF]
Journal of Experimental Medicine, 1897 Simon Flexner
exaly +2 more sources
Quantification of L-Abrine in Human and Rat Urine: A Biomarker for the Toxin Abrin [PDF]
Journal of Analytical Toxicology, 2009 Abrin is a toxic protein found in the jequirity seed. L-Abrine (N-methyl-tryptophan) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. Analysis of L-abrine was added to an existing method for quantifying ricinine as a marker for ricin exposure in human urine and analytically validated.
Rudolph C. Johnson +6 more
openalex +3 more sources
Chimerolectins: Classification, structural architecture, and functional perspectives. [PDF]
Protein SciAbstract Lectins are proteins or glycoproteins capable of binding specifically and reversibly to carbohydrates, a property that, in itself, gives them great functional versatility in organisms from all kingdoms of nature. A subclass of these proteins, called chimerolectins, is composed of proteins that have at least one lectin domain associated with ...
Pinto-Junior VR +2 more
europepmc +2 more sources