The complete primary structure of abrin-a B chain [PDF]
FEBS Letters, 1992 The complete 267 amino acid sequence of abrin‐a B chain was determined by analysis of peptides obtained by digestion with trypsin, chymotrypsin, lysyl endopeptidase, Staphylacaccus aureus V8 protease and thermolysin. The sequence is not identical with that predicted previously by nucleotide sequencing, indicating the presence of isoforms of abrin ...
Lu-Ping Chow, Jung-Yaw Lin, A Tsugita
exaly +4 more sources
Equal Neutralization Potency of Antibodies Raised against Abrin Subunits
Antibodies, 2020 Abrin and ricin are potent AB toxins, which are considered biological threats. To date, there are no approved treatments against abrin or ricin intoxications.
Yoav Gal +9 more
doaj +2 more sources
Detection of Abrin Holotoxin Using Novel Monoclonal Antibodies
Toxins, 2017 Abrin, a member of the ribosome-inactivating protein family, is produced by the Abrus precatorius plant. Having the potential to pose a severe threat to both human and animal health, abrin is classified as a Select Agent by the U.S.
Xiaohua He +7 more
doaj +2 more sources
A monoclonal antibody to an abrin chimera recognizing a unique epitope on abrin A chain confers protection from abrin-induced lethality [PDF]
Human Vaccines & Immunotherapeutics, 2015 Abrin, obtained from the seeds of Abrus precatorius plant, is a potent toxin belonging to the family of type II ribosome-inactivating proteins. Recently, a recombinant vaccine consisting of the A subunits of abrin and its homolog Abrus precatorius agglutinin (APA) was demonstrated to protect mice from abrin lethality.
Kumar, Meenakshi Sundaram +1 more
openaire +4 more sources
A Neutralizing Antibody to the A Chain of Abrin Inhibits Abrin Toxicity both In Vitro and In Vivo [PDF]
Clinical and Vaccine Immunology, 2008 ABSTRACTPlant ribosome-inactivating proteins (RIPs) are RNA N-glycosidases that inhibit protein synthesis in cells. Abrin, a type II RIP, is an AB type toxin, which is one of the most lethal types of toxin known. The B chain facilitates the entry of the molecule into the cell, whereas the A chain exerts the toxic effect.
Surendranath, Kalpana, Karande, Anjali A
openaire +3 more sources
Mechanistic insights into the neutralization of cytotoxic abrin by the monoclonal antibody D6F10. [PDF]
PLoS ONE, 2013 Abrin, an A/B toxin obtained from the Abrus precatorius plant is extremely toxic and a potential bio-warfare agent. Till date there is no antidote or vaccine available against this toxin.
Shradha Bagaria +3 more
doaj +2 more sources
Differential Thermal Inactivation Enables Simultaneous Quantitation of Ricin and Abrin [PDF]
ToxinsRicin and abrin are highly lethal Type II ribosome-inactivating proteins. They depurinate the same site of the 28S rRNA to inhibit protein synthesis. Consequently, standard molecular-level activity assays used to detect the toxic activity of ricin or ...
Woo-Hyeon Jeong
doaj +2 more sources
Rapid Differential Detection of Abrin Isoforms by an Acetonitrile- and Ultrasound-Assisted On-Bead Trypsin Digestion Coupled with LC-MS/MS Analysis [PDF]
Toxins, 2021 The high toxic abrin from the plant Abrus precatorius is a type II ribosome-inactivating protein toxin with a human lethal dose of 0.1–1.0 µg/kg body weight.
Long-Hui Liang +6 more
doaj +2 more sources
Chimerolectins: Classification, structural architecture, and functional perspectives. [PDF]
Protein SciAbstract Lectins are proteins or glycoproteins capable of binding specifically and reversibly to carbohydrates, a property that, in itself, gives them great functional versatility in organisms from all kingdoms of nature. A subclass of these proteins, called chimerolectins, is composed of proteins that have at least one lectin domain associated with ...
Pinto-Junior VR +2 more
europepmc +2 more sources
Development and Evaluation of an Immuno-MALDI-TOF Mass Spectrometry Approach for Quantification of the Abrin Toxin in Complex Food Matrices [PDF]
Toxins, 2021 The toxin abrin found in the seeds of Abrus precatorius has attracted much attention regarding criminal and terroristic misuse over the past decade. Progress in analytical methods for a rapid and unambiguous identification of low abrin concentrations in ...
Sandrine Livet +7 more
doaj +2 more sources