Results 51 to 60 of about 3,204 (212)

Nano‐Oncologicals: A Tortoise Trail Reaching New Avenues

Advanced Functional Materials, Volume 31, Issue 44, October 26, 2021., 2021
This is a critical review of the applications of nanotechnology for the improvement of oncological treatments based both on synthetic and biological molecules to target either tumor or immune cells. An overview of the early beginnings of the field, together with the most relevant formulations in clinical and preclinical evaluation, is also provided ...
Tamara G. Dacoba, Shubaash Anthiya, Germán Berrecoso, Iago Fernández‐Mariño, Carmen Fernández‐Varela, José Crecente‐Campo, Desirée Teijeiro‐Osorio, Fernando Torres Andón, María J. Alonso   +8 more
wiley   +1 more source

New Immunotherapeutic Approaches for Glioblastoma

Journal of Immunology Research, Volume 2021, Issue 1, 2021., 2021
Glioblastoma (GBM) is the most common primary malignant brain tumor with a high mortality rate. The current treatment consists of surgical resection, radiation, and chemotherapy; however, the median survival rate is only 12–18 months despite these alternatives, highlighting the urgent need to find new strategies.
Gustavo Ignacio Vázquez Cervantes, Dinora F. González Esquivel, Saúl Gómez-Manzo, Benjamín Pineda, Verónica Pérez de la Cruz, Xiao-Jie Lu   +5 more
wiley   +1 more source

Llama-Derived Single Domain Antibodies Specific for Abrus Agglutinin

Toxins, 2011
Llama derived single domain antibodies (sdAb), the recombinantly expressed variable heavy domains from the unique heavy-chain only antibodies of camelids, were isolated from a library derived from llamas immunized with a commercial abrin toxoid ...
James P. Carney, Rachael Bernstein, Eric A. E. Garber, Jennifer L. Walker, Thomas W. O’Brien, Alena Calm, Jinny L. Liu, Ellen R. Goldman, Scott Walper, Dan Zabetakis, George P. Anderson   +10 more
doaj   +1 more source

Nanocarrier mediated intracellular delivery of neutralizing antibodies for the management of abrin lethality

Biomedical Research Journal, 2017
Abrin is a highly lethal ribosome-inactivating protein of high relevance in bio-warfare. Neutralizing antibodies to abrin reported so far afford protection in a very small window with no rescue observed post-abrin exposure.
Meenakshi Sundaram Kumar, Ambily Abraham, Handanahal S Savithri, Anjali A Karande   +3 more
doaj   +1 more source

Structure-function analysis and insights into the reduced toxicity of Abrus precatorius agglutinin I in relation to abrin

, 2006
Abrin and agglutinin-I from the seeds of Abrus precatorius are type II ribosome-inactivating proteins that inhibit protein synthesis in eukaryotic cells.
Bagaria, A., Ramagopal, U.A., Ramakumar, S., Surendranath, K., Karande, A.A.   +4 more
core   +2 more sources

Rapid and quantitative detection of Shiga toxin1 and Shiga toxin2 based on multiple targets UPT‐LF assay

Engineering in Life Sciences, Volume 20, Issue 11, Page 494-503, November 2020., 2020
Abstract Shiga toxin‐producing Escherichia coli (STEC) infection causes a series of diseases that are highly pathogenic and deadly in humans and animals, seriously endangering public health. Of the pathogenic factors within STEC, the two groups of Shiga toxin (Stx) consisting Stx1 and Stx2 plays a prominent role in the pathogenesis of STEC infection ...
Qiaozhen Wei, Qiushi Hu, Fengjuan Shi, Shuang Li, Chongsi Sun, Huicong Zhang, Lei Xue, QiuXia Feng, Jinying Dong, Yongjun Jiao, Lei Zhou   +10 more
wiley   +1 more source

Scallop mantle toxin induces apoptosis in liver tissues of mice

Food Science &Nutrition, Volume 8, Issue 7, Page 3308-3316, July 2020., 2020
We had previously shown that the intake of scallop mantle tissue resulted in the death of mice and rats. In this study, we have investigated how liver tissue injuries are caused by the mantle toxin. Our results showed that the mantle toxin caused liver tissue apoptosis through the induction of oxidative stress, ER stress, and inflammation in the organ.
Takahide Kariya, Yasushi Hasegawa
wiley   +1 more source

Plant‐Derived Lectins as Potential Cancer Therapeutics and Diagnostic Tools

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Cancer remains a global health challenge, with high morbidity and mortality, despite the recent advances in diagnosis and treatment. Multiple compounds assessed as novel potential anticancer drugs derive from natural sources, including microorganisms, plants, and animals. Lectins, a group of highly diverse proteins of nonimmune origin with carbohydrate‐
Milena Mazalovska, J. Calvin Kouokam, Yearul Kabir   +2 more
wiley   +1 more source

Ricin as a Biothreat Agent: From Molecular Mechanisms to Clinical Toxicology, Forensic Aspects, and Risk Mitigation

BioMed Research International, Volume 2026, Issue 1, 2026.
Ricin, a potent ribosome‐inactivating protein derived from the seeds of Ricinus communis L., represents a significant threat in the context of biological warfare and terrorism due to its high toxicity, ease of extraction, and lack of a specific antidote.
Miroslav Pohanka, Poorani Gurumallesh Prabu   +1 more
wiley   +1 more source

Risks for human health related to the presence of plant lectins in food

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract The European Commission asked the European Food Safety Authority (EFSA) to assess the risk related to the presence of plant lectins in food. Based on the available evidence, the CONTAM Panel considered only phytohaemagglutinin (PHA), a legume lectin from beans (Phaseolus sp.), for the risk characterisation.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Hanne Frøkiær, Bettina Grasl‐Kraupp, Patrick Mulder, Pierre Rougé, Heather Wallace, Marios Georgiadis, José Ángel Gómez Ruiz, Eirini Kouloura, Olaf Mosbach‐Schulz, Lydia Alarcón Asensio, Eleni Gkimprixi, Evangelia Ntzani   +30 more
wiley   +1 more source