Results 51 to 60 of about 4,965 (233)
Immunotoxins and Anticancer Drug Conjugate Assemblies: The Role of the Linkage between Components [PDF]
, 2011 Immunotoxins and antibody-drug conjugates are protein-based drugs combining a target-specific binding domain with a cytotoxic domain. Such compounds are potentially therapeutic against diseases including cancer, and several clinical trials have shown ...
Franco Dosio, Luigi Cattel, Paola Brusa
core +3 more sources
Engineering in Life Sciences, Volume 20, Issue 11, Page 494-503, November 2020., 2020 Abstract Shiga toxin‐producing Escherichia coli (STEC) infection causes a series of diseases that are highly pathogenic and deadly in humans and animals, seriously endangering public health. Of the pathogenic factors within STEC, the two groups of Shiga toxin (Stx) consisting Stx1 and Stx2 plays a prominent role in the pathogenesis of STEC infection ...
Qiaozhen Wei +10 more
wiley +1 more source
Scallop mantle toxin induces apoptosis in liver tissues of mice
Food Science &Nutrition, Volume 8, Issue 7, Page 3308-3316, July 2020., 2020 We had previously shown that the intake of scallop mantle tissue resulted in the death of mice and rats. In this study, we have investigated how liver tissue injuries are caused by the mantle toxin. Our results showed that the mantle toxin caused liver tissue apoptosis through the induction of oxidative stress, ER stress, and inflammation in the organ.
Takahide Kariya, Yasushi Hasegawa
wiley +1 more source
CCD Based Detector for Detection of Abrin Toxin Activity
Toxins, 2020 Abrin is a highly potent and naturally occurring toxin produced in the seeds of Abrus precatorius (Rosary Pea) and is of concern as a potential bioterrorism weapon.
Reuven Rasooly +2 more
doaj +1 more source
The analgesic effects of anti-inflammatory drugs from the point of view of different pharmacological test methods [PDF]
, 1964 1. The forms of irritation causing inflammation and pain are reviewed, with reference to the significance of histamine, serotonin and bradykinin and in particular to the interrelationship between inflammation and pain. 2.
Wilhelmi, G.
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Plant‐Derived Lectins as Potential Cancer Therapeutics and Diagnostic Tools
BioMed Research International, Volume 2020, Issue 1, 2020., 2020 Cancer remains a global health challenge, with high morbidity and mortality, despite the recent advances in diagnosis and treatment. Multiple compounds assessed as novel potential anticancer drugs derive from natural sources, including microorganisms, plants, and animals. Lectins, a group of highly diverse proteins of nonimmune origin with carbohydrate‐
Milena Mazalovska +2 more
wiley +1 more source
Differential rates of perinatal maturation of human primary and nonprimary auditory cortex [PDF]
, 2018 Primary and nonprimary cerebral cortex mature along different timescales; however, the differences between the rates of maturation of primary and nonprimary cortex are unclear.
Brownell, Abraham +9 more
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Chemosensors, 2022 Abrin is a cytotoxin with strong lethality, which is a serious threat to human health and public safety, and thus, highly sensitive detection methods are urgently needed.
Shuai Liu +9 more
doaj +1 more source
Simultaneous Detection of Ricin and Abrin DNA by Real-Time PCR (qPCR)
Toxins, 2012 Ricin and abrin are two of the most potent plant toxins known and may be easily obtained in high yield from the seeds using rather simple technology. As a result, both toxins are potent and available toxins for criminal or terrorist acts. However, as the
Roman Wölfel +3 more
doaj +1 more source
"Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery? [PDF]
, 2007 Some pathogens utilize unique routes to enter cells that may evade the intracellular barriers encountered by the typical clathrin-mediated endocytic pathway.
Medina-Kauwe, LK
core +1 more source