Results 61 to 70 of about 2,553 (186)

Phage Display Affibodies Combined with AuNPs@Ru(bpy)₃²⁺ for Ultra-Sensitive Electrochemiluminescence Detection of Abrin

Chemosensors, 2022
Abrin is a cytotoxin with strong lethality, which is a serious threat to human health and public safety, and thus, highly sensitive detection methods are urgently needed.
Shuai Liu, Zhaoyang Tong, Chunying Jiang, Chuan Gao, Jianjie Xu, Xihui Mu, Bing Liu, Bin Du, Zhiwei Liu, Pengjie Zhang   +9 more
doaj   +1 more source

Acute Toxicity and Genotoxicity of cMoL, a Lectin From Moringa oleifera Seeds With Antifungal Activity Against Cryptococcus Strains

Journal of Applied Toxicology, Volume 46, Issue 2, Page 682-696, February 2026.
ABSTRACT Coagulant Moringa oleifera lectin (cMoL) is one of the compounds involved in the application of M. oleifera seeds for traditional water treatment methods. The present study highlights the new biotechnological potential of cMoL lectin as an antifungal agent against Cryptococcus neoformans B3501 and H99 and Cryptococcus gattii R265 strains ...
Matheus Cavalcanti de Barros, Sávia Soraia Santana da Silva, Eduarda Pinto Gagliano, Alícia Natalie Silva dos Santos, Leydianne Leite de Siqueira Patriota, Gustavo Ramos Salles Ferreira, Pollyanna Michelle da Silva, Simone da Paz Leôncio Alves, Julliano Matheus de Lima Maux, Jacinto da Costa Silva Neto, Fernanda Rafaelly Nascimento de Santana, Fabiana Aparecida Cavalcante Silva, Marilene Henning Vainstein, Luana Cassandra Breitenbach Barroso Coelho, Thâmarah de Albuquerque Lima, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva   +16 more
wiley   +1 more source

Ricin as a Biothreat Agent: From Molecular Mechanisms to Clinical Toxicology, Forensic Aspects, and Risk Mitigation

BioMed Research International, Volume 2026, Issue 1, 2026.
Ricin, a potent ribosome‐inactivating protein derived from the seeds of Ricinus communis L., represents a significant threat in the context of biological warfare and terrorism due to its high toxicity, ease of extraction, and lack of a specific antidote.
Miroslav Pohanka, Poorani Gurumallesh Prabu   +1 more
wiley   +1 more source

A biophysical elucidation for less toxicity of Agglutinin than Abrin-a from the Seeds of Abrus Precatorius in consequence of crystal structure

Journal of Biomedical Science, 2010
X-ray crystal structure determination of agglutinin from abrus precatorius in Taiwan is presented. The crystal structure of agglutinin, a type II ribosome-inactivating protein (RIP) from the seeds of Abrus precatorius in Taiwan, has been determined from ...
Liu Chao-Lin, Lu Tian-Huey, Cheng Jack, Lin Jung-Yaw   +3 more
doaj   +1 more source

Ethnobotanical Survey of Medicinal Plants Utilized by Traditional Healers in Managing Respiratory Tract Infections in the Kagera Region, Tanzania

The Scientific World Journal, Volume 2026, Issue 1, 2026.
Respiratory tract infections (RTIs) are the primary cause of morbidity and mortality in many low‐and middle‐income countries. In most of these countries, including Tanzania, medicinal plants (MPs) are primarily used to manage various ailments, though the majority are not yet documented.
Neema Gideon Mogha, Pamela Epaphra Sola, Elbert Anyambilile Mbukwa, Olivia John Kalokora, Sultan Zahiruddin   +4 more
wiley   +1 more source

Risks for human health related to the presence of plant lectins in food

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract The European Commission asked the European Food Safety Authority (EFSA) to assess the risk related to the presence of plant lectins in food. Based on the available evidence, the CONTAM Panel considered only phytohaemagglutinin (PHA), a legume lectin from beans (Phaseolus sp.), for the risk characterisation.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Hanne Frøkiær, Bettina Grasl‐Kraupp, Patrick Mulder, Pierre Rougé, Heather Wallace, Marios Georgiadis, José Ángel Gómez Ruiz, Eirini Kouloura, Olaf Mosbach‐Schulz, Lydia Alarcón Asensio, Eleni Gkimprixi, Evangelia Ntzani   +30 more
wiley   +1 more source

From WGS to gels: Development and testing of PCR primers targeting toxic Digitalis in support of food safety

Applications in Plant Sciences, Volume 13, Issue 5, September-October 2025.
Abstract Premise This study capitalized on a library of single‐nucleotide polymorphisms created via whole genome sequencing (WGS) to develop and test a PCR assay for detecting toxic Digitalis species in food products. Complex foods can be difficult to analyze, but safeguarding consumer well‐being and public health necessitates that products regulated ...
Elizabeth Sage Hunter, Sydnee Fo, Robert Literman, Richard H. Uva, Jennifer L. Wolny, Sara M. Handy   +5 more
wiley   +1 more source

Abrin activates DNA damage signaling pathway.

, 2014
Phosphorylation of H2AX (γH2AX) was analysed in Jurkat cells (A) treated with abrin (10 ng/ml) for different time intervals (0–10 h) (B) pretreated with broad spectrum caspase inhibitor, z-VAD.fmk for 2 h and then with abrin or (C) with gamma radiation ...
Ritu Mishra (541530), Anjali A. Karande (385296)   +1 more
core   +1 more source

Exploring Cytotoxic mRNAs as a Novel Class of Anti-cancer Biotherapeutics

Molecular Therapy: Methods & Clinical Development, 2018
New treatments to overcome the obstacles of conventional anti-cancer therapy are a permanent subject of investigation. One promising approach is the application of toxins linked to cell-specific ligands, so-called immunotoxins.
Kristin Hirschberger, Anita Jarzebinska, Eva Kessel, Verena Kretzschmann, Manish K. Aneja, Christian Dohmen, Annika Herrmann-Janson, Ernst Wagner, Christian Plank, Carsten Rudolph   +9 more
doaj   +1 more source

Antibodies in breast milk: Pro‐bodies designed for healthy newborn development

Immunological Reviews, Volume 328, Issue 1, Page 192-204, November 2024.
Summary This manuscript sheds light on the impact of maternal breast milk antibodies on infant health. Milk antibodies prepare and protect the newborn against environmental exposure, guide and regulate the offspring's immune system, and promote transgenerational adaptation of the immune system to its environment.
Valerie Verhasselt, Julie Tellier, Rita Carsetti, Burcu Tepekule   +3 more
wiley   +1 more source