Results 131 to 140 of about 761,190 (342)
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Studies of the Properties of Bouillon Filtrates of the Meningococcus: Production of a Soluble Toxin [PDF]
, 1931 N. S. Ferry +2 more
openalex +1 more source
Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation
Molecular Oncology, EarlyView.Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza +5 more
wiley +1 more source
The Treatment of Inoperable Sarcoma by Bacterial Toxins (the Mixed Toxins of the Streptococcus erysipelas and the Bacillus prodigiosus). [PDF]
, 1910 WILLIAM B. COLEY
openalex +1 more source
, 2009 Lethal intoxications of animals dwelling in aquatic habitats are recurrently observed with blooms of cyanobacteria. The latter produces two types of toxins : cytotoxins & biotoxins and a few antibiotics (allelopaths) such as acutiphycins, indolcarbazoles, tantazoles, tolytoxins etc.
Garg, HK, Garg, Jaya
openaire +1 more source
Molecular Oncology, EarlyView.Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun +5 more
wiley +1 more source
The charybdotoxin receptor of a Shaker K+ channel: peptide and channel residues mediating molecular recognition. [PDF]
, 1994 Charybdotoxin (CTX) is a peptide of known structure that inhibits Shaker K+ channels by a pore-blocking mechanism. Point mutagenesis of all 30 solvent-exposed residues identified the part of the CTX molecular surface making contact with the receptor in ...
Goldstein, SA, Miller, C, Pheasant, DJ
core
The Histological Evidence that Toxins reach the Spinal Cord via the Spinal Roots; with Special Reference to Plasma-Cells [PDF]
, 1910 David Orr, R. G. Rows
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Identifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng +13 more
wiley +1 more source