Results 141 to 150 of about 875,495 (362)

The adjuvant effect of manganese on tuberculosis subunit vaccine Bfrb-GrpE

open access: yesnpj Vaccines
Protein subunit vaccines, lacking pathogen-associated molecular patterns that trigger immune responses, rely on adjuvants to induce robust immune responses against the target pathogen.
Shuai Zhou   +11 more
doaj   +1 more source

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

open access: yesFEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang   +6 more
wiley   +1 more source

Emerging analytical frontiers in microplastic detection: From spectroscopy to smart sensor technologies

open access: yesTalanta Open
Microplastics (MPs) and nanoplastics (NPs), defined as synthetic polymeric particles smaller than 5 mm and 1 μm, respectively, have emerged as pervasive and persistent pollutants across aquatic, terrestrial, and atmospheric environments, as well as ...
Jen-Tai Lin   +12 more
doaj   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

open access: yesFEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu   +12 more
wiley   +1 more source

Toxins, Pathogenicity, Anti-Toxins, a Bicentennial Contribution

open access: yesToxins
The bicentenary of Louis Pasteur’s birth raises the opportunity to revisit the activity and influence of L [...]
Michel R. Popoff, Daniel Ladant
openaire   +3 more sources

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source

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