Results 61 to 70 of about 875,495 (362)
, 2023 The most often used medication in hospitals is oxygen, which is a crucial component in prehospital treatment. Prehospital providers administer oxygen to eliminate hypoxemia and hypoxia. Clinical settings of oxygen toxicity are categorized into acute oxygen toxin and habitual (chronic) oxygen toxin.
Pavan Eshwar Reddy.K +7 more
openaire +1 more source
Toxin–antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes
Nucleic Acids Research, 2005 Prokaryotic chromosomes code for toxin–antitoxin (TA) loci, often in multiple copies. In E.coli, experimental evidence indicates that TA loci are stress-response elements that help cells survive unfavorable growth conditions.
D. Pandey, K. Gerdes
semanticscholar +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Toxins, 2015 Botulinum neurotoxins (BoNT) are some of nature’s most potent toxins. Due to potential food contamination, and bioterrorism concerns, the development of detection reagents, therapeutics and countermeasures are of urgent interest.
Luisa W. Cheng +3 more
doaj +1 more source
Staphylococcus δ-toxin promotes mouse allergic skin disease by inducing mast cell degranulation
Nature, 2013 Atopic dermatitis is a chronic inflammatory skin disease that affects 15–30% of children and approximately 5% of adults in industrialized countries. Although the pathogenesis of atopic dermatitis is not fully understood, the disease is mediated by an ...
Y. Nakamura +12 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
JAMA: The Journal of the American Medical Association, 1901 Our object in presenting this paper is merely to outline the theory of the nature and action of the bacterial toxins which we are endeavoring to demonstrate, and to describe our method of work and the results which we have reached through the experiments we have so far made, which are very incomplete and really only a beginning toward the thorough ...
Thomas B. Cooley, Victor C. Vaughan
openaire +2 more sources
Biology Direct, 2012 BackgroundProteinaceous toxins are observed across all levels of inter-organismal and intra-genomic conflicts. These include recently discovered prokaryotic polymorphic toxin systems implicated in intra-specific conflicts.
Dapeng Zhang +5 more
semanticscholar +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source