Results 81 to 90 of about 983,459 (311)

Antifungal Drug Repurposing

Antibiotics, 2020
Control of fungal pathogens is increasingly problematic due to the limited number of effective drugs available for antifungal therapy. Conventional antifungal drugs could also trigger human cytotoxicity associated with the kidneys and liver, including ...
Jong H. Kim, Luisa W. Cheng, Kathleen L. Chan, Christina C. Tam, Noreen Mahoney, Mendel Friedman, Mikhail Martchenko Shilman, Kirkwood M. Land   +7 more
doaj   +1 more source

Further Characterization of Dopamine Release by Permeabilized PC 12 Cells [PDF]

, 1987
Rat pheochromocytoma cells (PC 12) permeabilized with staphylococcal α-toxin release [3H]dopamine after addition of micromolar Ca2+. This does not require additional Mg2+-ATP (in contrast to bovine adrenal medullary chromaffin cells).
Ahnert-Hilger G., Bader M. F., Bader M. F., Baker P. F., Bhakdi S., Bhakdi S., Brooks J. C., Dunn L. A., Ekerdt R., Flodgaard H., Gratzl M., Gudrun Ahnert-Hilger, Lowry O. H., Manfred Gratzl, Rubin R. P., Sillen L. G., Simon W., Wadstrom T., Wilson S. P.   +18 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Proteomic Profiling of Venoms from Bungarus suzhenae and B. bungaroides: Enzymatic Activities and Toxicity Assessment

Toxins
Kraits are venomous snakes of the genus Bungarus from the family Elapidae. Their venom typically demonstrates neurotoxicity; however, the toxicity is significantly influenced by the snake’s species and geographical origin.
Chenying Yang, Li Ding, Qiyi He, Xiya Chen, Haiting Zhu, Feng Chen, Wanzhou Yang, Yuexin Pan, Zhiyuan Tai, Wenhao Zhang, Zeyuan Yu, Zening Chen, Xiaodong Yu   +12 more
doaj   +1 more source

Augmenting the Antifungal Activity of an Oxidizing Agent with Kojic Acid: Control of Penicillium Strains Infecting Crops

Molecules, 2014
Oxidative treatment is one of the strategies for preventing Penicillium contamination in crops/foods. The antifungal efficacy of hydrogen peroxide (H2O2; oxidant) was investigated in Penicillium strains by using kojic acid (KA) as a chemosensitizing ...
Jong H. Kim, Kathleen L. Chan
doaj   +1 more source

The effects of storage conditions on viability of Clostridium difficile vegetative cells and spores and toxin activity in human faeces [PDF]

, 2003
AIMS: Clostridium difficile is a common nosocomial pathogen and as such diagnostic and research methods may necessitate storage of faecal specimens for long periods, followed by subsequent re-examination.
Freeman, J., Wilcox, M.H.
core   +1 more source

Paralytic Shellfish Toxins of Pyrodinium bahamense (Dinophyceae) in the Southeastern Gulf of Mexico [PDF]

, 2022
Erick J. Núñez-Vázquez, Carlos Antonio Poot-Delgado, Andrew D. Turner, Francisco E. Hernández-Sandoval, Yuri B. Okolodkov, Leyberth José Fernández-Herrera, José J. Bustillos-Guzmán   +6 more
openalex   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Membrane-Pore Forming Characteristics of the Bordetella pertussis CyaA-Hemolysin Domain

Toxins, 2015
Previously, the 126-kDa Bordetella pertussis CyaA pore-forming/hemolysin (CyaA-Hly) domain was shown to retain its hemolytic activity causing lysis of susceptible erythrocytes. Here, we have succeeded in producing, at large quantity and high purity, the
Chattip Kurehong, Chalermpol Kanchanawarin, Busaba Powthongchin, Gerd Katzenmeier, Chanan Angsuthanasombat   +4 more
doaj   +1 more source

Toxin-Antitoxin Gene Pairs Found in Tn3 Family Transposons Appear To Be an Integral Part of the Transposition Module

mBio, 2020
Much of the diversity of prokaryotic genomes is contributed by the tightly controlled recombination activity of transposons (Tns). The Tn3 family is arguably one of the most widespread transposon families.
Gipsi Lima-Mendez, Danillo Oliveira Alvarenga, Karen Ross, Bernard Hallet, Laurence Van Melderen, Alessandro M. Varani, Michael Chandler   +6 more
doaj   +1 more source