Results 31 to 40 of about 277,535 (215)

TcdC does not significantly repress toxin expression in Clostridium difficile 630ΔErm. [PDF]

PLoS ONE, 2012
In the past decade, Clostridium difficile has emerged as an important gut pathogen. Symptoms of C. difficile infection range from mild diarrhea to pseudomembranous colitis, sometimes resulting in colectomy or death.
Dennis Bakker, Wiep Klaas Smits, Ed J Kuijper, Jeroen Corver   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

RstA Is a Major Regulator of Clostridioides difficile Toxin Production and Motility

mBio, 2019
Clostridioides difficile infection (CDI) is a toxin-mediated diarrheal disease. Several factors have been identified that influence the production of the two major C. difficile toxins, TcdA and TcdB, but prior published evidence suggested that additional
Adrianne N. Edwards, Brandon R. Anjuwon-Foster, Shonna M. McBride   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Staphylococcus aureus nasal carriage in hemodialysis centers of Fez, Morocco

Iranian Journal of Microbiology, 2014
Background and objectives: Staphylococcus aureus (S. aureus) nasal carriage may be responsible for some serious infections in hemodialyzed patients. The main target of this study was to estimate the prevalence of S.
Idrissa Diawara, Khadija Bekhti, Driss Elhabchi, Rachid Saile, Naima Elmdaghri, Mohammed Timinouni, Mohamed Elazhari   +6 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

ANALYSIS OF THE PRESENCE OF TOXINS FROM ESCHERICHIA COLI, CLOSTRIDIUM PERFRINGENS, C. DIFFICILE IN BULK FEEDS OF SAINT-PETERSBURG AND LENINGRAD REGION

Siberian Journal of Life Sciences and Agriculture
Background. Undesirable microflora can enter forage crops during harvesting with soil, which can contain various pathogenic microorganisms, including clostridia and enterobacteria, which enter it when manure is applied to fields as fertilizer.
Valentina A. Filippova, Elena A. Yildirim, Larisa A. Ilina, Georgy Yu. Laptev, Andrey V. Dubrovin, Vasily A. Zaikin, Ksenia A. Kalitkina, Alisa S. Dubrovina, Ivan G. Malakhov, Irina A. Klyuchnikova   +9 more
doaj   +1 more source

Staphylococcal toxin genes in strains isolated from cows with subclinical mastitis Detecção de genes de toxinas em linhagens de estafilococos isolados de vacas com mastite subclínica

Pesquisa Veterinária Brasileira, 2008
The present study was carried out in 11 dairy herds in four municipal districts of the rural area of the State of Pernambuco, Brazil. Out of 984 quarter milk (246 cows), 10 (1.0%) were positive for clinical mastitis, 562 (57.1%) for subclinical mastitis ...
Manuela F.L. de Freitas, Isabelle da S. Luz, Vladimir da M. Silveira-Filho, José W.P. Júnior, Tânia L.M. Stamford, Rinaldo A. Mota, Maria J. de Sena, Alzira M.P. de Almeida, Valdir de Q. Balbino, Tereza C. Leal-Balbino   +9 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source